31/03/2022 - General information
The project "Tumour microenvironment-derived factors in localised colon cancer: clinical impact and therapeutic implications' (TuMiCC)"aimed at demonstrating the value of the tumour microenvironment in predicting relapse in patients with localised colon cancer treated with adjuvant therapy, has reached the 16-month development milestone, with patient recruitment and interesting advances in the molecular characterisation of this type of tumour and its environment.
30/03/2022 - General information
A study by the Neuroimmunology Research Group at the Hospital del Mar Medical Research Institute (IMIM) has validated a possible marker that could improve the efficiency of one of the main multiple sclerosis treatments. The marker is a specific type of immune system cell, known as NK (Natural Killer) cells, which express a specific receptor on their surface, NKG2C. Currently, patients with multiple sclerosis are treated with anti-CD20 monoclonal antibodies, which are designed to eliminate the B-lymphocyte population in peripheral blood and thus control disease activity. These drugs are scheduled to be administered once every six months, although it is unclear whether this time period is appropriate for all patients. Several studies indicate that, depending on the drug given, it takes between six months and a year and a half for the levels of the B-lymphocyte population to recover.
23/03/2022 - Events
From 25 April to 20 June, 2022, the series "Our brain, that great unknown" will be held in various libraries across Barcelona, supported by the Barcelona library network. This series is part of the "Visions of Science" project organised by the Barcelona Library network, and for the third year it has been entrusted to the Hospital del Mar Medical Research Institute (IMIM) thanks to the success of previous editions. The series will run for 8 weeks. Every Monday at 6:30 pm there will be free talks, open to everyone, on topics related to the brain, a complex and fascinating organ about which we still have a great deal to discover. In this series we will learn about the latest data provided by new scientific advances in this field thanks to the participation of leading experts from Hospital del Mar and the IMIM. We will find out everything from how the brain works and how it behaves in the face of illness to how emotions are seen in the brain and the latest brain surgery techniques.
23/03/2022 - General information
The European Research Network on Signal Transduction (ERNEST), of which IMIM is a member, has created an Emergency Fund for Ukrainian researchers. Researchers affiliated to any legal entity in Ukraine (for example, schools and universities, research centers, governmental institutions, or private companies) are eligible to apply for this funding. For more information you can contact Jana Selent (vice-chair of the ERNEST - Cost Action 18133) or visit this website
17/03/2022 - Press release
Researchers at the Hospital del Mar Medical Research Institute and Hospital del Mar have transformed immunotherapy-resistant tumours into tumours that respond to this treatment, achieving cures in animal models through an innovative therapeutic strategy in triple-negative breast cancer, the most aggressive subtype. Researchers have discovered the essential role of a new factor, LCOR, in enabling cancer cells to present tumour antigens on their surfaces. These antigens allow the immune system to recognise the tumour, an essential step if immunotherapy treatment is to succeed. On the other hand, they have shown that cancer stem cells have very low levels of LCOR, making them invisible to the immune system and therefore resistant to treatment. The work that has just been published used an innovative experimental messenger RNA system, similar to the technology used for COVID-19 vaccines, to produce LCOR in tumour cells. In this way, the resistant tumour cells of triple-negative cancer become visible and sensitive to the immune system. This approach is also being investigated in other breast cancer subtypes
Més informació "Radical increase in the effectiveness of breast cancer immunotherapy"
22/03/2022 - Press release
In contrast, exposure to environmental pollutants such as fine particulate matter, nitrogen dioxide and soot significantly increases the risk of suffering an ischaemic stroke. The article in the journal Environment International, one of the most important studies published to date in Europe, analysed data from the entire population in Catalonia, geo-referencing more than three and a half million people. The authors consider that these results mean that the maximum levels of atmospheric pollutants established by the EU need to be reconsidered. The risk of suffering an ischaemic stroke, the most common type of cerebrovascular event, is 16% less in people who have green spaces less than 300 metres from their homes. This has been revealed in a joint study by the Hospital del Mar Medical Research Institute, Hospital del Mar, the Catalan Health Quality and Assessment Agency (AQuAS) from the Catalan Government's Department of Health and the Barcelona Institute for Global Health (ISGlobal), a centre promoted by the "la Caixa" Foundation. It is the most important work in this field to date in Europe, analysing data on the entire population of Catalonia between 2016 and 2017.
Més informació "Living near green areas reduces the risk of suffering a stroke by 16%"
17/02/2022 - General information
An IMIM-Hospital del Mar research project aimed at analyzing the mechanisms that generate resistance to immunotherapy treatment in metastatic breast cancer has been selected by the Metastatic Breast Cancer Association in the third edition of this award. The project, headed by doctors Toni Celià-Terrassa and Joan Albanell, will receive 100,000 euros for its development. This afternoon saw the presentation of the III M. Chiara Giorgetti Award for research into metastatic breast cancer. This year it recognises a project from the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar), led by doctors Toni Celià-Terrassa and Joan Albanell. The award is promoted by the Metastatic Breast Cancer patients' association and involves a prize of 100,000 euros, 25,000 euros of which are provided by the AMAMA association.
Més informació "M. Chiara Giorgetti Award for a Hospital del Mar Medical Research Institute project"
17/02/2022 - Press release
New research associates the presence of Caudovirales in gut microbiota to an improvement in cognitive functions and memory in humans, mice and flies. The results show that bacteriophages present in the gut microbiota influence the relationship between the microbiome and the brain The article, published in the journal Cell Host & Microbe, was led by Dr. Jordi Mayneris-Perxachs and Dr. José Manuel Fernández-Real, of the Nutrition, Eumetabolism and Health group of the Girona Biomedical Research Institute (IDIBGI) Dr. Josep Trueta and CIBEROBN, and has been carried out in collaboration with the Neuropharmacology research group led by Dr. Rafael Maldonado of Pompeu Fabra University and attached to the Hospital del Mar Medical Research Institute (IMIM); the FISABIO Foundation, the University of Valencia (UV) and the University of Alicante (UA).
14/02/2022 - General information
In addition, 71% of them claim to have a poor quality of life due to epileptic seizures, according to a study carried out by Hospital del Mar's Epilepsy Unit. Women suffer higher levels of depression and anxiety, as well as a poorer quality of life, compared to men. The results obtained raise the issue of how to address these factors as triggers of epileptic seizures. This is the largest study to date analysing psychiatric comorbidities in patients with this type of pathology. The work has been published in the journal Frontiers in Neurology. People diagnosed with treatment-resistant epilepsy have high levels of depression and anxiety, as well as a poor quality of life, according to a study published in the journal Frontiers in Neurology by Hospital del Mar's Epilepsy Unit . In fact, half of these patients suffer from depression and anxiety and more than 70% claim to have a poor quality of life. This fact suggests that a global approach to these patients should be evaluated, taking into account the psychiatric aspects of their pathology to try to control their epileptic seizures.
10/02/2022 - General information
The Hospital del Mar Medical Research Institute and Hospital del Mar are once again supporting the International Day of Women and Girls in Science, raising awareness of their work and trying to encourage new vocations. In the case of the IMIM, just over half of the research positions are held by women. In the 21st century, women who decide to pursue a career in the various fields of science often receive smaller research grants than their male colleagues. They hold only 12% of the positions in national science academies, while they account for a third of all researchers. Realities that make an initiative like the International Day of Women and Girls in Science and campaigns such as She Inspired Me more necessary than ever.
Més informació "Towards full and equal access to and participation in science for women and girls"
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