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GPCR drug discovery Jana Selent

Publications 2024 (11)

• Gaitonde SA, Avet C, de la Fuente-Revenga M, Blondel-Tepaz E, Shahraki A, Morales A, Talagayev V, Robledo P, Kolb P, Selent J, Gonzalez-Maeso J, Bouvier M^*. Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT(2A) receptor. Mol Psychiatr 2024: (en Premsa).
• López M, Stepniewski T, Kogut-Günthel MM, Di Pizio A, Rosenkilde MM, Mao J, Selent J^*. Relevance of G protein-coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation. Br J Pharmacol 2024: (en Premsa).
• Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, López M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A^*. The path to the G protein-coupled receptor structural landscape: Major milestones and future directions. Br J Pharmacol 2024: (en Premsa).
• Nerin F, Caprai C, Morales A, López M, Aranda D, Giorgino T^*, Selent J^*. AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks. Comput Struct Biotechnol J . 2024; 23: 1938-1944 (Acceptat).
• Pham U, Chundi A, Stepniewski T, Darbha S, Eiger DS, Gazula S, Gardner J, Hicks C, Selent J, Rajagopal S^*. Location-biased β-arrestin conformations direct GPCR signaling. bioRxiv . 2024: .
• Papadopoulos MGE, Perhal AF, Medel-Lacruz B, Ladurner A, Selent J, Dirsch VM, Kolb P^*. Discovery and characterization of small-molecule TGR5 ligands with agonistic activity. Eur J Med Chem 2024; 276: 116616.
• Gareri C, Pfeiffer CT, Jiang X, Paulo JA, Gygi SP, Pham U, Chundi A, Wingler LM, Staus DP, Stepniewski T, Selent J, Lucero EY, Grogan A, Rajagopal S, Rockman HA^*. Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways. Sci Signal 2024; 17(849): eadk5736.
• Kossatz E, Diez-Alarcia R, Gaitonde SA, Ramon-Duaso C, Stepniewski T, Aranda D, Muneta-Arrate I, Tepaz E, Saen-oon S, Soliva R, Shahraki A, Moreira D, Brea J, Loza MI, de la Torre R, Kolb P, Bouvier M, Meana JJ, Robledo P^*, Selent J^*. G protein-specific mechanisms in the serotonin 5-HT(2A) receptor regulate psychosis-related effects and memory deficits. Nat Commun 2024; 15(1): 4307.
• Nowicki K^*, Krajewska J, Stepniewski T, Wielechowska M, Winska P, Kaczmarczyk A, Korpowska J, Selent J, Marek-Urban PH, Durka K, Wozniak K, Laudy AE^*, Lulinski S^*. Exploiting thiol-functionalized benzosiloxaboroles for achieving diverse substitution patterns - synthesis, characterization and biological evaluation of promising antibacterial agents. RSC Med Chem . 2024; 15(5): 1751-1772 (Acceptat).
• Morales A. Characterization of allosteric communication networks in GPCRs. Universitat Pompeu Fabra. Director: Selent J. Fecha lectura: 16/04/2024.
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• Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski T, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R^*, Nureki O^*, Shukla AK^*. Molecular insights into atypical modes of ?-arrestin interaction with seven transmembrane receptors. Science 2024; 383(6678): 101-108.