26/10/2021 - Press release
The risk of death from any cause increases by 30% for each 10 beat per minute increase above 70 beats per minute The study, led by researchers at the Hospital del Mar Medical Research Institute, analysed data from more than 10,000 participants in the REGICOR study to establish the relationship between heart rate and the risk of cardiovascular disease and death It is a simple measurement indicator, which also provides information on the risk of cardiovascular disease. The work has been published in the European Journal of Preventive Cardiology
Més informació "A higher heart rate is associated with a greater risk of death"
19/10/2021 - Press release
Activating a molecule present in the membrane of NK lymphocytes (Natural Killer cells) makes them resistant to the immunosuppressive mechanisms of HER2-positive breast tumours and enhances their antitumour action. Combining standard treatments for HER2-positive breast cancer with drugs that target this molecule in NK cells could increase their clinical efficacy. This paves the way for a new approach to treating this type of tumour with immunotherapy This has been demonstrated in a collaborative study led by researchers at the Hospital del Mar Medical Research Institute, published in the journal Cancer Immunology Research
These are obese patients with no associated diseases, referred to as metabolically healthy, who account for one in five people who undergo bariatric surgery. Their levels of cholesterol, glucose, triglycerides and fatty liver markers continue to fall five years after surgery The improvement is less than that seen in obese patients who do have metabolic problems prior to undergoing surgery and who, therefore, start from higher levels, but it demonstrates the usefulness of applying this surgical procedure to these individuals This has been demonstrated in a study by the Endocrinology and Nutrition Service at Hospital del Mar, the first in Spain, published in the journal Surgery for Obesity and Related Diseases
Més informació "Bariatric surgery improves long-term health of metabolically healthy obese patients"
1/10/2021 - Press release
Patients with chronic obstructive pulmonary disease (COPD) who also suffer from a blood iron deficiency significantly improve their physical fitness if they receive supplements of this mineral. This is a new approach to the disease, which has been validated by the first studies published in Spain in this field and the largest in the world, to date, involving 66 patients. The work, derived from the FACE-Ferinject Assessment study on improving Exercise Tolerance in patients suffering COPD and iron deficiency, was carried out by doctors and researchers in the Pneumology Department at Hospital del Mar and the Hospital del Mar Medical Research Institute (IMIM) and has been published in the journals Archivos de Bronconeumología and Biomedicines.
Més informació "Iron supplements improve physical fitness and quality of life in COPD patients"
16/09/2021 - Press release
Older adults who are overweight or obese who stick most closely to the Mediterranean diet preserve their cognitive performance and even improve their abilities after three years, according to a study led by researchers at the Hospital del Mar Medical Research Institute and the CIBEROBN, published in the journal Clinical Nutrition. Memory improvements are proportional to the level of adherence to the Mediterranean diet, weight loss and increased physical activity. At the same time, these changes translate into improvements in people's quality of life. The work is based on the PREDIMED-PLUS trial and shows that women and people with less education gain less benefit on a cognitive level from this type of dietary intervention. This leads the researchers to support the personalization of these approaches in order to maximize the benefit.
Més informació "The Mediterranean diet helps improve cognitive function and memory"
12/08/2021 - Press release
A study led by doctors and researchers from Hospital del Mar, the Hospital del Mar Medical Research Institute (IMIM), and CIBER Oncology (CIBERONC) has demonstrated the role a protein, neuregulin, plays in generating resistance to the most common treatment for HER2-positive breast cancer, one of the most aggressive types. The study, published in the journal Clinical Cancer Research, and in which leading Italian researchers Luca Gianni from the Fondazione Gianni Bonnadonna and Giampaolo Bianchini from the IRCCS Ospedale San Raffaele have collaborated, has identified that in patients with high levels of this protein, the success rate with the monoclonal antibody trastuzumab, the first-line drug, drops. Conversely, when combined with another monoclonal antibody, pertuzumab, the situation is reversed and full pathological response levels are restored.
06/08/2021 - Press release
A Hospital del Mar project to determine new prognostic and predictive markers that could be beneficial in metastatic small cell lung cancer treatment, using genetic analysis techniques, has been awarded $200,000 from the Oncomine Clinical Research Grant programme, promoted by the US-based multinational biotech company Thermo Fisher Scientific, which supports research that enables advances in the field of molecular patient profiling, with the aim of improving clinical outcomes. The research was led by Dr. Edurne Arriola, head of the lung cancer section in the Medical Oncology Service and a researcher at the Hospital del Mar Medical Research Institute (IMIM), and Dr. Beatriz Bellosillo, head of the Medical Oncology Service and also an IMIM researcher. To undertake the project, they will analyse samples from 300 patients with this pathology, collected over the last 10 years. The research will focus on evaluating the potential of the liquid biopsy technique, which can detect DNA from tumour cells in the blood, to monitor the disease and its evolution, as well as detecting potential biomarkers of treatment benefit and predictors of long-term prognosis.
Més informació "$200,000 grant for lung cancer research at Hospital del Mar"
29/07/2021 - Press release
Researchers from the G-protein-coupled receptor-based drug development research group at the Hospital del Mar Medical Research Institute (IMIM) have been able to verify, with a degree of precision never before achieved, how the process that triggers the response of neurones in the brain occurs. This is an essential mechanism for understanding how moods or even processes such as addictions are produced, and in which neurotransmitters, molecules that help transmit information between neurones through specialised receptors, the G protein-coupled receptors (GPCRs), play a vital role. "Neurotransmission is one of the most crucial physiological processes, as its dysregulation can result in various neuropsychiatric disorders", explains Dr. Jana Selent, principal author of the study, published in the journal Chemical Science, and coordinator of the research group that led the work. Very small changes in how information is transmitted by these molecules can trigger different reactions in the brain, some of which are linked to behaviour, addictions and moods.
Més informació "Mechanism that triggers brain neurone response revealed"
21/07/2021 - Press release
Levels of omega-3 fatty acids in the blood are as good a predictor of mortality from any cause as smoking, according to a study involving the Hospital del Mar Medical Research Institute (IMIM), in collaboration with The Fatty Acid Research Institute in the United States and several universities in the United States and Canada. The study, published in The American Journal of Clinical Nutrition, used data from a long-term study group, the Framingham Offspring Cohort, which has been monitoring residents of this Massachusetts town, in the United States, since 1971. Researchers have found that omega-3 levels in blood erythrocytes (the so-called red blood cells) are very good mortality risk predictors.
Combining chemotherapy with a BRAF oncogene inhibitor proves effective at treating this disease. The study, published in the journal Oncogene, was led by researchers from the Hospital del Mar Medical Research Institute, Hospital del Mar and CIBERONC. This alternative paves the way towards a new approach for patients affected by this type of tumor, which has no cure in the most advanced stages or cases of relapse.
Més informació "A new approach to metastatic melanoma discovered"
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