Researchers from the Hospital del Mar Research Institute have published a new article in Microbiology Spectrum proposing a novel approach to treating pneumonia caused by antibiotic-resistant Pseudomonas aeruginosa bacteria. The study suggests that increasing the dose of the antibiotic colistin may not only be ineffective, but could also increase patient mortality. For this reason, the researchers advocate for using nebulized administration of the treatment instead of intravenous administration. This approach achieves higher concentrations in the lungs, where the infection is located, without causing toxic colistin concentrations in the blood. The World Health Organization considers antibiotic resistance among the top 10 global public health threats.
A study involving the Hospital del Mar Research Institute, the Vall d'Hebron Institut d'Oncologia, IDIBELL, and the Institut Català d'Oncologia suggests that combining chemotherapy with drugs that can inhibit two cell signaling pathways involved in tumor progression may aid in treatment. The research has analyzed the interaction of the protein IKKα with these pathways, known for their ability to promote the proliferation of tumor cells. This combination has the advantage of reducing treatment toxicity. The study opens the door to new approaches for tumors with the presence of this protein. It is published in the EMBO Journal.
Més informació "A possible new combination of treatments to combat cancer"
05/10/2023 - Press release
A study led by researchers at the Hospital del Mar Research Institute identifies that the deterioration of the blood-brain barrier, which regulates exchanges between the blood and the brain, can be used to identify which of these patients will have a more rapid progression. In the patients analysed, the risk of accelerated disease progression increases by 8% for every 10% increase in the level of albumin in cerebrospinal fluid and blood (a biomarker of damage to the blood-brain barrier). The results indicate that restoring the blood-brain barrier's ability to protect the brain could help slow the worsening of patients. This marker will allow a more accurate assessment of the prognosis of patients with cognitive impairment caused by Alzheimer's and other dementias. The work is published in the journal Alzheimer's&Dementia.
27/09/2023 - Press release
Research conducted in a mouse model identifies the neurobiological mechanism responsible for alterations in the memory of young individuals exposed to alcohol during pregnancy and lactation. This study proposes a therapy that can reverse the deficit, paving the way for treating a disorder that is underdiagnosed in humans.
18/09/2023 - Press release
Researchers from the UAB, the Gregorio Marañón Health Research Institute, and the Hospital del Mar Research Institute have published the first article reviewing research conducted to date on the neurobiological adaptation of women to motherhood by analysing the relation of hormones, brain and behaviour during pregnancy and the postpartum period.
17/08/2023 - Press release
This is highlighted in a study published in Diabetes Metabolism Research and Reviews, sponsored by the Erasmus University of Rotterdam, the Hospital del Mar and the Hospital del Mar Research Institute. The paper highlights the role of glycans, the sugars that envelop one of the most common blood antiglycans, immunoglobulin G. Depending on their combination, patients' prognosis changes and they are more likely to present microvascular complications, such as nephropathy, or macrovascular, such as cardiac problems. This environment can be modified by changes in lifestyle and diet. This fact makes it a potential therapeutic target.
10/08/2023 - Press release
A team from the Hospital del Mar Research Institute has, for the first time, detected fetal DNA in the olfactory neuroepithelium of women who have given birth to a boy. A new study will now be launched, which will also analyze female fetal DNA. The team of researchers has been able to confirm that women with depression had much lower levels of cells from newborns than those who were not suffering from this disorder. This discovery paves the way to studying the DNA exchange between the mother and the fetus during pregnancy as a factor that protects women against depression, as well as its relationship with other psychiatric disorders.
28/07/2023 - Press release
Cannabis use disorder (CUD) affects over 14 million individuals in the US.? Despite the urgent need, there are no FDA-approved medications to treat CUD; behavioral treatments have shown limited benefit. AEF0117 is the first of a new pharmacologic class, type 1 cannabinoid receptor signaling-specific inhibitors (CB1-SSi), with a unique mechanism of action and greater safety and efficacy than prior generations of CB1 inhibitors.? In a phase 2a clinical study in volunteers with CUD, AEF0117 produced statistically significant reductions in the positive subjective and reinforcing effects of smoked cannabis.
14/07/2023 - Press release
The prevalence of childhood obesity is higher among male participants (14.9%) and in the population aged 8 to 12 years (15.6%). It is confirmed once again that the childhood obesity epidemic in Spain presents a socioeconomic gradient: children enrolled in schools with a lower average income per person have a higher level of obesity. The Gasol Foundation study, carried out with the support of the Hospital del Mar Research Institute, shows a deterioration in eating habits, use of screens, hours of sleep, physical activity, emotional well-being and quality of life among children aged 8 to 16 years in Spain.
21/06/2023 - Press release
The Molecular Mechanisms of Cancer and Stem Cell Research Group of the Hospital del Mar Research Institute is the only center in Spain to participate in an international study that validates the deficiency of a protein, IκBα, as a marker of poor prognosis in this type of tumor The work, published in Cell Reports Medicine, has analyzed data from more than 2,000 patients. In addition, the researchers have identified one of the pathways on which this protein acts, which makes it a possible therapeutic target The Hospital del Mar Research Institute group is already working on a model to search for possible treatments that modulate the function of this marker. It should be considered that at present there are very few therapeutic alternatives for glioma, which has a very high mortality rate
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