2019
Stem Cells and Cancer
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Cancer Programme
Our research group studies the molecular mechanisms involved in the generation and maintenance of healthy stem cells and their differentiation to functional cells. We particularly focus in studying signaling pathways and their activation effects that control the hematopoietic system. Our goal is to understand how these signals are important in the generation of hematopoietic stem cells during embryonic development, maintenance of these cells in adulthood and how these signals are perturbed in leukemic processes.
Group Leader
Anna Bigas Salvans
Research group
Members
Violeta García Hernández (Researcher)
Yolanda Guillén Montalbán (Researcher)
Teresa Lobo Jarne (Researcher)
Roshana Thambyrajah (Researcher)
David Arambilet Morilla (PhD Student)
Luis Galán Palma (Phd Student)
Jèssica González Miranda (Technician)
Arnau Iglesias Piqueras (Technician)
Main Publications
• Colomer C, Margalef P, Villanueva A, Vert A, Pecharromán I, Solé L, González-Farré M, Alonso J, Montagut C, Martínez-Iniesta M, Bertran J, Borràs E, Iglesias M, Sabidó E, Bigas A, Boulton SJ, Espinosa L. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell. 2019; 75(4): 669-682. IF 14.548. Q1.
Ongoing Research Projects
• Hematopoietic and leukemic stem cell specification
- Financing institution: Ministerio de Economía y Competitividad (SAF2016 -75613-R)
- Period: from 2017 to 2019
- Principal investigator: Bigas Salvans, Anna
• Exploring mechanisms of resistance in adult and paediatric T-Acute Lymphoblastic leukemia
- Financing institution: Asociación Española Contra el Cáncer (AECC), Programa de ayuda a grupos estables
- Period: from 2016 to 2021
- Principal investigator at IMIM and coordinator: Bigas Salvans, Anna
• Hematopoietic regeneration from ES Cells
- Financing institution: Generalitat de Catalunya (PERIS-SLT002/16/00299)
- Period: from 2017 to 2019
- Principal investigator at IMIM and coordinator: Bigas Salvans, Anna
• Human disease modelling of GATA2-related Myelodysplastic Syndromes and Acute Myeloid Leukemia (GATA2-Humo)
- Financing institution: EraPerMed, (H2020), Departament de Salut, Generalitat de Catalunya
- Period: from 2019 to 2022
- Amount: 942,369 €
- Coordinator: Alessandra Giorgetti
- Principal investigator at IMIM: Bigas Salvans, Anna
Participation in Research Networks
• CIBER Cancer
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB16/12/00244)
- Period: from 2017 to 2019
- Principal investigator: Bigas Salvans, Anna
Outreach
Conferences, Seminars and Courses
• Anna Bigas. Invited Speaker. Seminar series DKFZ. Heidelberg, 12 April 2019.
• Anna Bigas. Speaker and organizer. IJC Opening Symposium on Genetics and Epigenetics of Leukemia and Lymphoma. Badalona, September 2019.
• Anna Bigas. Invited Speaker. The Notch Meeting. Athens, October 2019.
Dissemination to Society and Initiatives of Citizen Participation
• Students of the Centre d’Estudis Montseny visit the Laboratory of the Stem Cells and Cancer Group. ACCÉS Project (Bringing Science Closer to Secondary Schools) included in the Escolab Project. Barcelona Science Programme of the Institute of Culture. 25 January 2019.
• Anna Bigas. What can we do with stem cells and where do we want to get? UniStem Day at the BST (Tissue and Blood Bank), 15 March 2019.
• Visit to the Laboratory of the Stem Cells and Cancer Group. Escolab Project. Barcelona Science Programme of the Institute of Culture. 25 January 2019.
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es