The mission of the Neurosciences Research Programme (NRP) is to support clinical research, which ultimately should give us a better understanding of mental and neurodegenerative diseases. The Programme is formed by 13 research groups with a clinical orientation.

Outstanding scientific achievements

During 2019, NRP coordinated an Alzheimer Association (PENSA) project and participated as partner in several H2020 research projects: GO-DS21, MINDUP and other international projects funded by the University of Maastricht, Jérôme Lejeune Foundation, NEURON-ERANET and JPND.

Some scientific publications

• Olesti E, Farré M, Carbó ML, Papaseit E, Perez-Mañá C, Torrens M, Yubero-Lahoz S, Pujadas M, Pozo ÓJ, de la Torre R. Dose-Response Pharmacological Study of Mephedrone and Its Metabolites: Pharmacokinetics, Serotoninergic Effects, and Impact of CYP2D6 Genetic Variation. Clin Pharmacol Ther. 2019 Sep; 106(3): 596-604.

• Rodríguez-Morató J, Goday A, Langohr K, Pujadas M, Civit E, Pérez-Mañá C, Papaseit E, Ramon JM, Benaiges D, Castañer O, Farré M, de la Torre R. Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity. Sci Rep. 2019 Dec 31; 9(1): 20405.

• Ramon-Duaso C, Gener T, Consegal M, Fernández-Avilés C, Gallego JJ, Castarlenas L, Swanson MS, de la Torre R, Maldonado R, Puig MV, Robledo P. Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression. Cereb Cortex. 2019 Jul 5; 29(7): 2978-2997.

• Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C, Muñoz D, Barbosa F, Morales JC, Gaedigk A, Langohr K, Covas MI, Pérez-Mañá C, Fitó M, Tyndale RF, de la Torre R. Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial. Free Radic Biol Med. 2019 Nov 1; 143: 471-481.

• Olesti E, De Toma I, Ramaekers JG, Brunt TM, Carbó ML, Fernández-Avilés C, Robledo P, Farré M, Dierssen M, Pozo ÓJ, de la Torre R. Metabolomics predicts the pharmacological profile of new psychoactive substances. J Psychopharmacol. 2019 Mar; 33(3): 347-354.

• Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, Maldonado R, Ozaita A. Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. Neurobiol Dis. 2019; 125: 92-106.