Neurovascular
<
Inflammatory and Cardiovascular Disorders Programme
Group Leader
Jaume Roquer González
This is a clinical group involved in stroke research. Currently our group is included in the Red de Enfermedades Vasculares Cerebrales (INVICTUS PLUS) that is one of the main Spanish research networks. The strengths of our group are: first, our ongoing database named BASICMAR, that contains extensive demographic, epidemiological, clinical, and outcome data about all stroke patients (n=8,300) admitted to our hospital, and second, our large collection of blood sample of stroke patients for genetic and biomarkers studies (n=6,000). The two main research lines are:
1. Clinical research and biomarkers in stroke: epidemiology, natural history and vascular risk factors, stroke biomarkers, environmental and stroke, diet and stroke, neurosonology and neuro-imaging.
2. Genetic and stroke research: our unit is part of the International Stroke Genetics Consortium, which includes many international (USA, Europe) and national groups and of the GENESTROKE Consortium working to develop GWAS and EWAS studies and projects.
Research group
Members
Carla Avellaneda Gómez (Researcher)
Elisa Cuadrado Godia (Researcher)
Eva Giralt Steinhauer (Researcher)
Jordi Jiménez Conde (Researcher)
Ángel Javier Ois Santiago (Researcher)
Ana María Rodríguez Campello (Researcher)
Carolina Soriano Tárraga (Researcher)
Eva Langa Muñoz (Technician)
Uxue Lazcano Dobao (Technician)
Irene Navalpotro Gómez (Technician)
Gemma Romeral Ballester (Technician)
Miguel Ángel Rubio Pérez (Technician)
Rosa Maria Vivanco Hidalgo (Technician)
Main Publications
• Mola-Caminal M, Carrera C, Soriano-Tárraga C, Giralt-Steinhauer E, Díaz-Navarro RM, Tur S, Jiménez C, Medina-Dols A, Cullell N, Torres-Aguila NP, et al. PATJ low frequency variants are associated with worse ischemic stroke functional outcome: a genome-wide meta-analysis. Circulation Res 2019; 124: 114-120. IF 15.862. Q1.
• Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jiménez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, et al; International Stroke Genetics Consortium. Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis. JAMA Neurol 2019; 76: 480-491. IF 12.321. D1.
• Roquer J, Vivanco-Hidalgo RM, Prats-Sánchez LL, Martínez-Domeño A, Guisado-Alonso D, Cuadrado-Godia E, Giralt Steinhauer E, Jiménez-Conde J, Rodríguez-Campello A, Martí-Fàbregas J, Ois A. Interaction of atrial fibrillation and antithrombotics on outcome in intracerebral hemorrhage. Neurology 2019; 93: e1820-e1829. IF 8.689. D1.
• Ois A, Vivas E, Figueras-Aguirre G, Guimaraens L, Cuadrado-Godia E, Avellaneda C, Bertran-Recasens B, Rodríguez-Campello A, Gracia MP, Villalba G, Saldaña J, Capellades J, Fernández-Candil JL, Roquer J. Misdiagnosis worsens prognosis in subarachnoid hemorrhage with good Hunt & Hess score. Stroke 2019; 50: 3072-3076. IF 6.058. D1.
• Vivanco-Hidalgo RM, Avellaneda-Gómez C, Dadvand P, Cirach M, Ois A, Gómez-González A, Rodríguez-Campello A, de Ceballos P, Basagaña X, Zabalza A, Sunyer J, Cuadrado-Godia E, Roquer J, Wellenius GA. Association of residential air pollution, noise, and greenspace with initial ischemic stroke severity. Environ Res 2019; 179 (PtA): 108725. IF 5.026. D1.
Ongoing Research Projects
• Evaluación a nivel poblacional del impacto de la contaminación atmosférica sobre la incidencia y pronóstico del ictus isquémico
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI18/00056)
- Period: from 2019 to 2021
- Principal investigator: Roquer González, Jaume; Vivanco Hidalgo, Rosa M.
• Contribución de la epigenética en el pronóstico del ictus. Estudio de EWAS y Micro-RNAs circulantes
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI18/00022)
- Period: from 2019 to 2021
- Principal investigator: Jiménez Conde, Jordi; Rodríguez Campello, Ana.
• The Chemical Optimization of Cerebral Embolectomy (CHOICE) Trial
- Financing institution: Fundació La Marató de TV3 (20170732)
- Period: from 2018 to 2021
- Principal investigator: Cuadrado Godia, Elisa
Participation in Research Networks
• Red de Enfermedades Vasculares Cerebrales. INVICTUS PLUS.
- Financing institution: Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS (RD16/0019/0002)
- Period: from 2016 to 2021
- Principal investigator: Roquer González, Jaume
Clinical Trials Signed in 2019
• Estudio internacional de fase 2, aleatorizado, doble ciego, controlado con placebo, de búsqueda de dosis adaptada a la respuesta, de BMS-986177, un inhibidor del factor XIa oral, para la prevención de los nuevos casos de ictus isquémico o de infarto cerebral silente en pacientes tratados con Aspirina y clopidogrel después de un ictus no hemorrágico agudo o un accidente isquémico transitorio (AIT)
- Protocol: CV010-031
- Sponsor: Bristol-Myers Squibb International Corporation (BMSIC)
- Budget: 144,000 €
- Principal investigator: Rodríguez Campello, Ana María
• Registro nacional de hemorragias intracerebrales (ARICH) en relación al tratamiento anticoagulante
- Protocol: VHI-PRO-2019-01
- Sponsor: Fundació Institut Recerca Hospital Vall d'Hebron
- Budget: No economic compensation
- Principal investigator: Rodríguez Campello, Ana María
Awards
• Jaume Roquer. TOP 20 award 2019 “Área de Sistema Nervioso”. Best neurological department 2019 in Spain. 20th Edition Hospitales TOP 20. Madrid, 18/12/19.
• European Certification by the European Stroke Organization. Hospital del Mar Stroke Center ESO. 11/12/19. First stroke center accredited in Spain.
Appointments
• Ana Rodríguez Campello. Secretary of the Stroke Group of the Societat Catalana de Neurologia.
• Ana Rodríguez Campello. National auditor of the European Stroke Organisation for acreditation of stroke units and stroke centers.
Outreach
Dissemination to Society and Initiatives of Citizen Participation
• Ana Rodríguez Campello. Ictus. Escola de Salut de la Barceloneta. Casal Gent Gran de la Barceloneta. Barcelona, 13 February 2019.
2019
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es