Myogenesis, Inflammation & Muscle Function
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Inflammatory and Cardiovascular Disorders Programme
Research group
Group Leader
Joaquim Gea Guiral
Our ongoing research is focused on the role played by proinflammatory cytokines as a signaling molecules in the repairing-remodeling processes in muscles of patients with different processes with a relevant systemic inflammatory component, which share muscle dysfunction and/or loss of muscle mass. The strategic outcome is to identify potential molecular targets of therapies against muscle dysfunction and muscle cachexia. Our research is mainly addressed to lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) and lung cancer, but also muscle problems in aging, fibromyalgia and scoliosis and includes clinical assessment, in vivo and in vitro physiological studies, and molecular biology procedures.
More recently, we have initiated a line for the identification of molecular markers of different circumstances present in COPD patients (e.g. gravity, activity, comorbidities, systemic manifestations), using both conventional and ‘omics’ methodologies (transcriptomics, proteomics and metabolomics).
Members
Pilar Ausín Herrero (Researcher)
Carme Casadevall Fusté (Researcher)
Antoni Ferrer Monreal (Researcher)
Juana María Martínez Llorens (Researcher)
Sergi Pascual Guardia (Researcher)
Diego Agustín Rodríguez Chiaradia (Researcher)
Ana Balañá Corberó (PhD Student)
Eva Balcells Vilarnau (PhD Student)
Roberto Chalela Rengifo (PhD Student)
Mireia Admetlló Papiol (Technician)
Lucilla Piccari (Technician)
Main Publications
• Marín-Corral J, Dot I, Boguña M, Cecchini L, Zapatero A, Gracia MP, Pascual-Guardia S, Vilà C, Castellví A, Pérez-Terán P, Gea J, Masclans JR. Structural differences in the diaphragm of patients following controlled vs assisted and spontaneous mechanical ventilation. Intensive Care Med 2019; 45(4): 488-500. IF 18.967. D1.
• Chalela R, Bellosillo B, Curull V, Longarón R, Pascual-Guardia S, Badenes-Bonet D, Arriola E, Sánchez-Font A, Pijuan L, Gea J. EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma. J Clin Med 2019; 8(4): 529. IF 5.688. D1.
• Gea J, Pascual S, Castro-Acosta A, Hernández-Carcereny C, Castelo R, Márquez-Martín E, Montón C, Palou A, Faner R, Furlong LI, Seijo L, Sanz F, Torà M, Vilaplana C, Casadevall C, López-Campos JL, Monsó E, Peces-Barba G, Cosío BG, Agustí A; on behalf of the group BIOMEPOC. The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease. Arch Bronconeumol 2019; 55(2): 93-99. IF 4.214. Q1.
• Barreiro E, Salazar-Degracia A, Sancho-Muñoz A, Aguiló R, Rodríguez-Fuster A, Gea J. Endoplasmic reticulum stress and unfolded protein response in diaphragm muscle dysfunction of patients with stable chronic obstructive pulmonary disease. J Appl Physiol 2019; 126(6): 1572-1586. IF 3.140. Q1.
• Barreiro E, Sancho-Muñoz A, Puig-Vilanova E, Salazar-Degracia A, Pascual-Guardia S, Casadevall C, Gea J. Differences in micro-RNA expression profile between vastus lateralis samples and myotubes in COPD cachexia. J Appl Physiol 2019 F; 126(2): 403-412. IF 3.140. Q1.
Ongoing Research Projects
• Biomarcadores y perfiles clínicos personalizados en la Enfermedad Pulmonar Obstructiva Crónica
- Financing institution: Ministerio de Economía y Competitividad. Instituto de Salud Carlos III (SAF2014-54371-R)
- Period: from 2015 to 2019
- Principal investigator: Gea Guiral, Joaquim
• Deficiencia de hierro en pacientes con EPOC: Impacto de la reposición con hierro. FACE study (Ferinject Assessment in patients with COPD and iron deficiency to improve Exercise tolerance)
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI17/00649)
- Period: from 2018 to 2020
- Principal investigator: Rodríguez Chiaradia, Diego Agustín
Participation in Research Networks
• CIBER in Respiratory Diseases (CIBERES). Stable funding from the Spanish network of excellence in respiratory diseases
- Financing institution: Instituto de Salud Carlos III (CB06 / 06/0043)
- Period: from 2016 to 2019
• MERMAIDS (Platform foR European Preparedness Against (Re)emerging Epidemics, PREPARE)
- Financing institution: European Commission. Oxford University (coordinating center). Ref: 2014-602525.
- Period: from 2017 to 2022
Clinical Trials Signed in 2019
• Impacto de un programa de asistencia al paciente (PAP) en la persistencia al tratamiento con pirfenidona en pacientes con fibrosis pulmonar idiopática
- Register: ML40261
- Principal investigator: Balcells Vilarnau, Eva
Appointments
• Joaquim Gea Guiral. President of the Comité de Grados Universitarios of the Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
• Joaquim Gea Guiral. President of the Barcelona Respiratory Network Foundation
• Joaquim Gea Guiral. Member of the Advisory Board GlaxoSmithKline
• Joaquim Gea Guiral. Member of the Advisory Board AstraZeneca
• Joaquim Gea Guiral. Member of the Advisory Board Boehringer Ingelheim
• Joaquim Gea Guiral. Member of the Working Group to prepare the ERS statement on respiratory muscle testing at rest and during exercises of the European Respiratory Society (ERS)
• Joaquim Gea Guiral. Member of the Management Council of the European Board for Accreditation on Pneumology (EBAP)
• Joaquim Gea Guiral. Member of the Working Group for the improvement of the degree studies in Medicine of the Consell Interuniversitari de Catalunya (CIC), Generalitat de Catalunya
• Joaquim Gea Guiral. Member of the Working Group for the New Studies Plan of the Universitat Pompeu Fabra Medicine degree (PSMAR-UPF).
Outreach
Dissemination to Society and Initiatives of Citizen Participation
• Visit to the Laboratory of the Research Group of Myogenesis, Inflammation & Muscle Function. Open Day of the Parc de Recerca Biomèdica de Barcelona (PRBB), 5 October 2019.
• Juana María Martínez Llorens. Atenció Multidisciplinària a l’ELA. IV Jornada sobre ELA per a pacients, familiars i cuidadors. 3 May 2019.
• Anna Balañá. Workshop Maneig de secrecions respiratòries. IV Jornada sobre ELA per a pacients, familiars i cuidadors. 3 May 2019.
2019
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(+34) 93 316 04 00
info@imim.es