Musculoskeletal Research
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Inflammatory and Cardiovascular Disorders Programme
Group Leader
Francesc Xavier Nogués Solan
Our research focuses on the study of musculoskeletal disorders and the underlying mechanisms of bone pathophysiology. The group covers three main areas of research: genetics, epidemiology, and bone quality.
In the genetics field, we are exploring the genetic basis of bone disorders for both complex diseases such as osteoporosis and rare disorders such as monogenic skeletal dysplasias. In this line, we are active members of the GEMSTONE, a European COST action for the study of the Genomics of MusculoSkeletal traits.
At population level, we are working in the epidemiology of bone outcomes using several cohorts: BARCOS, SIDIAP and B-ABLE, currently involved in ongoing studies related to bone health and frailty. The BARCOS cohort also belongs to the international GEFOS/GENOMOS consortium, which has performed several genome-wide studies and metanalyses. B-ABLE is a cohort of postmenopausal women with early breast cancer treated with aromatase inhibitors. SIDIAP is a database that provides anonymized clinical information as coded by primary care practitioners in Catalonia, covering more than 7 million patients. Moreover, we started a new frailty cohort (CohorFES), involving a number of Spanish centres in CIBERFES with the aim of finding trajectories to explain the worsening process of frailty.
Our research also encompasses a number of diseases and therapies that affect bone metabolism as a secondary outcome. These include HIV infection and antiretroviral therapies, atypical fractures due to bisphosphonate treatment and other diseases with bone involvement. Our group is a leading research group in the development of a novel, hand-held Reference Point Indentation (RPI) instrument, Osteoprobe®, which measures bone quality. Finally, our group is also working on the design of biomaterials and scaffolds for promoting the biointegration of implants in osseous and soft tissues.
Research group
Members
Adolf Díez Pérez (Researcher)
Leonardo Mellibovski Saidler (Researcher)
Guillem Saló Bru (Researcher)
Isabel Aymar Fábrega (Technician)
Carme Giménez Argente (Technician)
Abora Rial Villavecchia (Technician)
Carme Sánchez Galiano (Research Assistant)
Main Publications
• Díez-Pérez A, Marín F, Eriksen EF, Kendler DL, Krege JH, Delgado-Rodríguez M. Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis: A systematic review and meta-analysis. Bone. 2019; 120: 1-8. IF 4.36. Q1.
• Pineda-Moncusí M, Servitja S, Tusquets I, Díez-Pérez A, Rial A, Cos ML, Campodarve I, Rodríguez-Morera J, García-Giralt N, Nogués X. Assessment of early therapy discontinuation and health-related quality of life in breast cancer patients treated with aromatase inhibitors: B-ABLE cohort study. Breast Cancer Res Treat. 2019; 177(1): 53-60. IF 3.471. Q2.
• Prieto-Alhambra D, Moral-Cuesta D, Palmer A, Aguado-Maestro I, Bardají MFB, Brañas F, Bueno GA, Caeiro-Rey JR, Cano IA, Barres-Carsi M, Delgado LG, Salomó-Domènech M, Etxebarria-Foronda I, Ferrer BL, Mills S, Herrando LE, Mifsut D, Evangelista LDR, Nogués X, Pérez-Coto I, Blasco JM, Martín-Hernández C, Kessel H, Serra JT, Solis JR, Suau OT, Vaquero-Cervino E, Hernández CP, Mañas LR, Herrera A, Díez-Pérez A. The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study. Arch Osteoporos. 2019; 14(1): 56. IF 2.469. Q2.
• Díez-Pérez A, Brandi ML, Al-Daghri N, Branco JC, Bruyère O, Cavalli L, Cooper C, Cortet B, Dawson-Hughes B, Dimai HP, Gonnelli S, Hadji P, Halbout P, Kaufman JM, Kurth A, Locquet M, Maggi S, Matijevic R, Reginster JY, Rizzoli R, Thierry T. Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Aging Clin Exp Res. 2019; 31(10): 1375-1389. IF 2.331. Q3.
Ongoing Research Projects
• Análisis objetivo mediante geolocalización del perímetro de la marcha en pacientes con estenosis del canal lumbar
- Financing institution: Sociedad para el Estudio de las Enfermedades del Raquis (GEER)
- Period: from 2018 to 2020
- Principal investigator: Saló Bru, Guillem
• Estudio para la mejora de la calidad de vida en mujeres con cáncer de mama tratadas con inhibidores de aromatasa: cohorte B-ABLE
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/00818)
- Period: from 2017 to 2020
- Principal investigator: Nogués Solan, Francesc Xavier
Participation in Research Networks
• CIBER Frailty and Healthy Aging (CIBERFES)
- Financing institution: Fondo de Investigación Sanitaria-ISCIII. CIBER (CB16/10/00245)
- Period: from 2017 to 2020
- Principal investigator: Nogués Solan, Francesc Xavier
• GEnomics of MusculoSkeletal traits TranslatiOnal Network (GEMSTONE)
- Financing institution: European COST action CA18139
- Period: from 2019 to 2023
- Principal investigator: Rivadeneira, Fernando
• European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
- Financing institution: European working group
- Period: from 2019 to 2023
- Principal investigator: Rivadeneira, Fernando
Clinical Trials Signed in 2019
• Estudio de fases I/III integradas, aleatorizado, en doble ciego y multicéntrico, en mujeres posmenopáusicas con osteoporosis, comparativo de la farmacocinética, farmacodinamia, eficacia, seguridad e inmunogenia de GP2411 (producto biológico propuesto similar al denosumab) frente a Prolia® (producto autorizado en la UE)
- Protocol: CGP24112301
- Sponsor: HEXAL
- Budget: 88,425.6 €
- Principal investigator: Nogués Solan, Francesc Xavier
• Prospective study for the detection of patients with X-Linked Hypophosphatemia (XLH) and other FGF23-mediated Hypophosphatemic genetic disorders in ambulatory care and Hospital outpatient clinic settings: The Barcelona Hypophosphatemia Study
- Sponsor: Kyowa Kirin Farmaceutica SLU
- Budget: 84,200 €
- Principal investigator: Nogués Solan, Francesc Xavier
Theses
• Lerma E. Estudio del impacto de la infección por VIH en el metabolismo óseo. Universitat Autònoma de Barcelona
- Directors: Díez Pérez, Adolf; Knobel H.
- Date of defense: 03/06/2019
• Taymouri F. Reference data for bone material strength index (BMSI) measured by impact microindentation. Universitat Autònoma de Barcelona
- Directors: Díez Pérez, Adolf; Nogués Solan, Francesc Xavier
- Date of defense: 08/02/2019
Appointments
• Francesc Xavier Nogués Solan. Director of the Inflammatory and Cardiovascular Disorders Programme. IMIM. 28/05/2019.
Outreach
Conferences, Seminars and Courses
• Xavier Nogués, Adolfo Díez Pérez, Diana Ovejero. Impact microindentation training seminars. IMIM; November 2019.
• Xavier Nogués. Metástasis óseas de tumores sólidos. Fisiopatología de las metástasis óseas. Hospital del Mar, 12-13 September 2019.
• Xavier Nogués; Natalia Garcia Giralt. Organizing committee. SEIOMM Congress. Girona, 17-19 October 2019.
Dissemination to Society and Initiatives of Citizen Participation
• Natalia Garcia Giralt, Xavier Nogués. Guided visit to IMIM for high school students from Institut Lluís Peguera. 5 February 2019.
2019
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08003 Barcelona
(+34) 93 316 04 00
info@imim.es