Kidney Disease
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Inflammatory and Cardiovascular Disorders Programme
Group Leader
Julio Pascual Santos
The Kidney Research Group (GREN) at IMIM belongs to the Nephrology Department of Parc de Salut Mar, Barcelona, Spain. The Nephrology Department covers structured assistance to the renal patient in four areas: clinical nephrology, kidney transplantation, chronic kidney disease and hypertension-cardiovascular risk. The department has made a particular effort in the area of kidney transplantation, covering all transplant modalities (deceased donor, living donor, sensitized patients, ABO-incompatible, etc).
GREN also has a basic-translational lab, in which a number of biologists (pre and postdoc) work together with nephrology physicians to achieve research objectives in different specialized areas. It belongs to the Red de Investigación Renal (renal research network - REDinREN) and is recognized by AGAUR.
The group aims to clarify mechanisms involved in the onset and progression of kidney diseases through preclinical research into in vivo and in vitro models. This makes it possible to study the molecular mechanisms involved, and will thus help us to identify the treatment targets and new strategies against kidney disease.
We also aim to study new treatment targets and strategies in depth by performing controlled clinical trials and observational projects of great interest, while securing all levels of possible commitment: promoters, main researchers, collaboration in multicenter projects and own projects.
Our research focuses mainly on three research areas: diabetic kidney disease and early markers of chronic kidney disease (C. Barrios PI16/00620), resistant hypertension (A. Oliveras EC11-426 and PI16/01356), new pathogenetic and therapeutic targets in the field of kidney transplantation (J. Pascual and M. Crespo PI13/00598, PI16/00617) and kidney transplantation in old and frail patients (J. Pascual, PI19/0037).
Research group
Members
Carlos Enrique Arias Cabrales (Researcher)
Clara Barrios Barrera (Researcher)
Marta Crespo Barrio (Researcher)
Javier Gimeno Beltrán (Researcher)
Anna Oliveras Serrano (Researcher)
María José Pérez Sáez (Researcher)
Dàlia Raïch Regué (Researcher)
María Dolores Redondo Pachón (Researcher)
Marta Riera Oliva (Researcher)
Eva Rodríguez García (Researcher)
Laia Sans Atxer (Researcher)
Susana Vázquez González (Researcher)
Carla Cristina Burballa Tàrrega (PhD Student)
Sílvia Collado Nieto (PhD Student)
Laura Llinàs Mallol (PhD Student)
Vanesa Palau González (PhD Student)
Sara Álvarez Morales (Technician)
David Benito Guasch (Technician)
Anna Buxeda Porras (Technician)
Anna Faura Vendrell (Technician)
Montserrat Folgueiras López (Technician)
Adriana Sierra Ochoa (Technician)
Maria Vera Casanova (Techncian)
Main Publications
• Berger SP, Sommerer C, Witzke O, Tedesco H, Chadban S, Mulgaonkar S, Qazi Y, de Fijter JW, Oppenheimer F, Cruzado JM, Watarai Y, Massari P, Legendre C, Citterio F, Henry M, Srinivas TR, Vincenti F, Gutiérrez MPH, Martí AM, Bernhardt P, Pascual J; TRANSFORM investigators. Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from the TRANSFORM study. Am J Transplant 2019; 19(11):3018-3034. IF 7.163. D1.
• Montero N, Quero M, Melilli E, Pérez-Sáez MJ, Redondo-Pachón D, Bestard O, Crespo M, Cruzado JM, Pascual J. Mammalian Target of Rapamycin Inhibitors Combined With Calcineurin Inhibitors as Initial Immunosuppression in Renal Transplantation: A Meta-analysis. Transplantation 2019; 103(10):2031-2056. IF 4.743. D1.
• Llinàs-Mallol L, Redondo-Pachón D, Pérez-Sáez MJ, Raïch-Regué D, Mir M, Yélamos J, López-Botet M, Pascual J, Crespo M. Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study. Sci Rep 2019; 9(1):7453. IF 4.011. Q1.
• Palau V, Pascual J, Soler MJ, Riera M. Role of ADAM17 in kidney disease. Am J Physiol Renal Physiol 2019; 317(2):F333-F342- IF 3.323. Q1.
• Buxeda A, Redondo-Pachón D, Pérez-Sáez MJ, Bartolomé Á, Mir M, Pascual-Dapena A, Sans A, Duran X, Crespo M, Pascual J. Gender differences in cancer risk after kidney transplantation. Oncotarget 2019; 10(33):3114-3128.
Ongoing Research Projects
• Adherencia terapéutica en Hipertensión Arterial no controlada: detección selectiva y eficacia y efectividad de un programa para mejorar el cumplimiento (Athan)
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/01356)
- Period: from 2017 to 2019
- Principal investigator: Oliveras Serrano, Anna
• Anticuerpos HLA y no HLA en el rechazo del trasplante renal y mecanismos de lesión
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/00617)
- Period: from 2017 to 2020
- Principal investigator: Pascual Santos, Julio
• Estudio de metabolómica y glicómica para la identificación de biomarcadores de función y daño renal en la diabetes mellitus tipo 2
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/00620)
- Period: from 2017 to 2021
- Principal investigator: Barrios Barrera, Clara
• Estudi multicèntric, aleatoritzat per avaluar l'eficàcia de la individualització del risc immunològic basat en biomarcadors selectius (Disparitat d'Eplets HLA i Elispot IFN-Y), per optimitzar el tractament immunosupressor en pacients trasplantats renals de donant viu (BIOIMMUN)
- Financing institution: Departament de Salut de la Generalitat de Catalunya (SLT002/16/00183)
- Period: from 2017 to 2019
- Principal investigator: Crespo Barrio, Marta
Participation in Research Networks
• Red de Investigación Renal (REDINREN)
- Financing institution: Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS. RD16/0009/0013
- Period: from 2017 to 2022
- Principal investigator: Pascual Santos, Julio
Clinical Trials Signed in 2019
• Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo en dos etapas para caracterizar la eficacia, seguridad, tolerabilidad y farmacocinética de GZ/SAR402671 en pacientes con Enfermedad Renal Poliquística Autosómica Dominante (ERPAD) en riesgo de progresión rápida
- Protocol: EFC15392
- Sponsor: Sanofi Aventis, SA
- Budget: 182,475 €
- Principal investigator: Sans Atxer, Laia
• A Phase 3b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of TRC101 in Delaying Chronic Kidney Disease Progression in Subjects with Metabolic Acidosis
- Protocol: TRCA-303 (VALOR-CKD)
- Sponsor: TRICIDA
- Budget: 37,015 €
- Principal investigator: Collado Nieto, Silvia
• Efecto de semaglutida en comparación con placebo sobre la progresión de la insuficiencia renal en sujetos con diabetes de tipo 2 y nefropatía crónica
- Protocol: NN9535-4321
- Sponsor: Novo Nordisk A/S
- Budget: 95,333.26 €
- Principal investigator: Pascual Santos, Julio
• A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients
- Protocol: VKTX01
- Sponsor: Vitaeris
- Budget: 166,956.2 €
- Principal investigator: Crespo Barrio, Marta
• Semaglutide cardiovascular outcomes trial in patients with type 2 diabetes (SOUL)
- Protocol: EX9924-4473 (SOUL)
- Sponsor: Novo Nordisk Pharma S.A
- Budget: 153,000 €
- Principal investigator: Pascual Santos, Julio
• Ensayo en Fase III Sobre la Eficacia y Seguridad del Metilbardoxolona en Pacientes con Enfermedad Poliquística Renal Autosómica Dominante
- Protocol: 402-C-1808
- Sponsor: REATA
- Budget: 42,515.01 €
- Principal investigator: Sans Atxer, Laia
Theses
• Otero S. Marcadores alternativos de daño renal asociado a la diabetes. Universitat Autònoma de Barcelona
- Directors: Barrios Barrera, Clara; Pascual Santos, Julio
- Date of defense: 25/04/2019
Awards
• Marta Crespo. Premi a l’excel·lència investigadora del COMB. December 2019.
• M. Fernández, Y Martínez, E. Junyent, S. Collado. Resultados de la implantación de la consulta de ayuda a la decisión en la elección de terapia renal sustitutiva. XLIV Congreso Nacional de la SEDEN. Premio SEDEN Enfermedad Renal Crónica Avanzada. Coruña, 8-10 October 2019.
• Sara Núñez, Anna Buxeda, Laia Sans, Susana Vázquez, Julio Pascual, Anna Oliveras. XXVI Reunió de la Societat Catalana d’Hipertensió Arterial – XXXII Jornades Catalanes sobre Hipertensió Arterial. XX Award for best clinical case. 11 December 2019.
• P. Fernández-Llama, P. Armario, À. de la Sierra, A. Oliveras. Research award in Nephrology, 2019. Sociedad Española de Nefrología. September 2019.
Appointments
• Marta Crespo. Member of the board of the working group DESCARTES (Developing Education Science and Care for Renal Transplantation in European States) of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA). 2019
Outreach
Conferences, Seminars and Courses
• Marta Crespo, María José Pérez Sáez. Coordinators and teachers. Curso de Trasplante para Residentes de Nefrología. Sociedad Española de Nefrología (SEN). Alcalá de Henares, 14-16 November 2019.
• Marta Crespo, Dolores Redondo. Coordinators. Workshop HLA. XLIX Congreso de la Sociedad Española de Nefrología. A Coruña, 5-8 October 2019.
• María José Pérez-Sáez. Outcomes of frail patients after kidney transplantation. 56th EDTA Congress. Budapest, Hungary. 13-16 June 2019.
• María José Pérez-Sáez. I Curso de Trasplante para enfermeras de Nefrología. Barcelona, 21-28 March 2019.
Dissemination to Society and Initiatives of Citizen Participation
• Marta Crespo. Jornada Trasplante Renal de Donante Vivo. Hospital del Mar. May 2019.
• Marta Crespo. Què representa per a l’investigador posar en marxa el seu projecte de recerca gràcies a la suma d’esforços dels donants a La Marató, la primera iniciativa solidària del país? Masterclass de La Marató de TV3. Campus Hospital del Mar. 9 April 2019.
2019
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