2019
Colorectal Neoplasms Clinical and Translational Research Group
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Cancer Programme
Research group
Group Leader
Xavier Bessa Caserras
The main strategic objective is to further our understanding of the pathogenesis of various neoplastic colorectal processes, from polyps to colorectal cancer, as well as their prevention and treatment. Our research focuses on identifying the factors relating to the development of metachronous neoplastic lesions, particularly advanced colorectal adenomas, to improve patient monitoring, and study how the inflammatory response to surgery influences the oncological outcome, identifying disease progression biomarkers in patients with colorectal cancer. Ongoing projects are:
1) Optimization of the surveillance of colon polyps. Development of an index for the risk of recurrence based on environmental, clinical, morphological, histological and molecular factors.
2) Prevention of colorectal cancer in the intermediate-risk population by means of genomic and microbiomic biomarkers (CRIPREV) PERIS (SLT002/16/00398).
3) Evaluation of ctDNA and deep learning in the detection of minimal residual disease in invasive polyps (pTN1).
4) Validation of postoperative serum levels of VEGF as a predictive biomarker of recurrence after surgery in patients with CRC who have undergone surgery with curative intent (FAECP grant).
5) Metabolic phenotyping of patients with CRC who have undergone surgery with curative intent to develop a profile of metabolites as predictive biomarkers of recurrence (ISCIII grant).
6) Liquid biopsy to assess minimal residual disease after surgery for colorectal cancer: an insight into the association between anastomotic leak and tumor recurrence (ISCIII grant).
Members
Sandra Alonso Gonçálvez (Researcher)
Marco Antonio Álvarez González (Researcher)
Josep Maria Dedeu Cuscó (Researcher)
Luís Grande Posa (Researcher)
Lucas Ilzarbe Sánchez (Researcher)
Lucía Márquez Mosquera (Researcher)
Xavier Mayol Girbau (Researcher)
Marta Pascual Damieta (Researcher)
Miguel Pera Román (Researcher)
Silvia Salvans Ruiz (Researcher)
Agustín Seoane Urgorri (Researcher)
Cristina Álvarez Urturi (PhD Student)
Fausto Riu Pons (PhD Student)
M. Francisca Murciano Gonzalo (Technician)
Main Publications
• Albéniz E, Álvarez-González MA, Espinós JC, Nogales O, Guarner C, Alonso P, Rodríguez-Téllez M, Herreros-de-Tejada A, Santiago J, Bustamante-Balén M, Sánchez JR, Ramos-Zabala F, Valdivielso E, Martínez-Alcalá F, Fraile M, Elosua A, Guerra-Veloz MF, Beroiz BI, Capdevila F, Enguita-Germán M. Clip Closure After Resection of Large Colorectal Lesions With Substantial Risk of Bleeding. Gastroenterology 2019; 157(5): 1213-1221.e4. IF 19.233. D1.
• Puig I, López-Cerón M, Arnau A, Rosiñol Ò, Cuatrecasas M, Herreros-de-Tejada A, Ferrández Á, Serra-Burriel M, Nogales O, Vida F, de Castro L, López-Vicente J, Vega P, Álvarez-González MA, González-Santiago J, Hernández-Conde M, Díez-Redondo P, Sánchez LR, Gimeno-García AZ, Burgos A, García-Alonso FJ, Bustamante-Balén M, Martínez-Bauer E, Peñas B, Pellise M, EndoCAR group, Spanish Gastroenterological Association and the Spanish Digestive Endoscopy Society. Collaborators. Accuracy of the Narrow-band Imaging International Colorectal Endoscopic Classification System in Identification of Deep Invasion in Colorectal Polyps. Gastroenterology 2019; 156(1): 75-87. IF 19.233. D1.
• Vleugels JLA, Hassan C, Senore C, Cassoni P, Baron JA, Rex DK, Ponugoti PL, Pellise M, Parejo S, Bessa X, Arnau-Collell C, Kaminski MF, Bugajski M, Wieszczy P, Kuipers EJ, Melson J, Ma KH, Holman R, Dekker E, Pohl H. Diminutive Polyps With Advanced Histologic Features Do Not Increase Risk for Metachronous Advanced Colon Neoplasia. Gastroenterology 2019; 156(3): 623-634. IF 19.233. D1.
• Bleijenberg AGC, IJspeert JEG, Carballal S, Pellise M, Jung G, van Herwaarden YJ, Bisseling TM, Nagtegaal ID, van Leerdam ME, Spaander MCW, van Lelyveld N, Bessa X, Rodríguez-Alcalde D, Bastiaansen BAJ, de Klaver W, Bemelman WA, Bujanda L, Koornstra JJ, Rivero L, Rodríguez-Moranta F, Balaguer F, Dekker E. Low Incidence of Advanced Neoplasia in Serrated Polyposis Syndrome After (Sub)total Colectomy: Results of a 5-Year International Prospective Cohort Study. Am J Gastroenterol 2019; 114(9): 1512-1519. IF 10.241. D1.
• Bisschops R, Manning J, Clayton LB, Ng Kwet Shing R, Álvarez-González MA, MORA Study Group. Colon cleansing efficacy and safety with 1 L NER1006 versus 2 L polyethylene glycol + ascorbate: a randomized phase 3 trial. Endoscopy 2019; 51(1): 60-72. IF 6.381. D1.
Ongoing Research Projects
• Biomarcadores pronósticos de recurrencia tras cirugía del cáncer colorrectal: Estudio de los cambios metabólicos y del contenido proteico y de miRNA de las vesículas extracelulares
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI15/00458)
- Period: from 2016 to 2020
- Principal investigator: Pera Román, Miguel
• Early biomarkers in circulating a 4B7 + T cells to predict response to Vedolizumab in inflammatory bowel disease patients
- Financing institution: Takeda Pharmaceutical Company Limited (IISR-2016-101479)
- Period: from 2016 to 2019
- Principal investigator: Márquez Mosquera, Lucía
• Diverticulitis agua y peoplasia avanzada de colon. Cuando realizar la endoscopia. Estudio ADACOLON (Acute Diverticulitis Advanced COLOnic Neoplasia)
- Financing institution: Asociación Española de Gastroenterología
- Period: from 2019 to 2021
- Principal investigator: Seoane Urgorri, Agustín
• Monitorización intraoperatoria de los nervios autonómicos en la cirugía del cáncer de recto: estudio prospectivo para valorar los resultados funcionales urogenitales y anorectales
- Financing institution: Fundación Asociación Española de Coloproctología
- Period: from 2019 to 2021
- Principal investigator: Alonso Gonçálvez, Sandra
Clinical Trials Signed in 2019
• Retrospective observational study to describe treatment patterns and health care resource utilization associated with complex perianal fistula in Crohn's disease
- Protocol: IBD-5003
- Sponsor: Takeda Pharmaceutical Company Limited
- Budget: 7,500 €
- Principal investigator: Márquez Mosquera, Lucía
• Safety of IBD drugs during pregnancy and breastfeeding: mothers and babies outcomes (Dumbo registry)
- Protocol: GET-VED-2018-01
- Sponsor: Grupo Español de Trabajo de Enfermedad de Crohn y Colitis Ulcerosa (GETECCU)
- Budget: No economic compensation
- Principal investigator: Márquez Mosquera, Lucía
• Efecto de fluidoterapia agresiva frente a fluidoterapia no agresiva en la fase precoz de la pancreatitis aguda: ensayo clínico aleatorizado multicéntrico, estudio Waterfall
- Protocol: Waterfall-2019
- Sponsor: Hospital General Universitario de Alicante
- Budget: No economic compensation
- Principal investigator: Ilzarbe Sánchez, Lucas
Appointments
• Miguel Pera. Member of the International Committee. American Society of Colon and Rectal Surgeons. September 2019.
Outreach
Conferences, Seminars and Courses
• Xavier Bessa. Moderator. Controvèrsies en digestologia. XXIX Congrés de la Societat Catalana de Gastroenterologia. Parc de Salut Mar. Lleida, 30 January 2020.
• Actualización en la prevención del cáncer colorrectal (CCR). Controversias en el seguimiento de los pacientes con pólipos y antecedentes familiares de CCR (09/026597-MD). 102º Curso de Patología Digestiva “Avances en Patología Digestiva”. Hospital de Sant Pau. Barcelona, 21 November 2019.
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