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B Cell Biology

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Inflammatory and Cardiovascular Disorders Programme

Group Leader

Andrea Cerutti (ICREA Professor)

Members of the B Cell Biology research group use different cellular, histological, and molecular techniques to address basic questions related to B cell activation and antibody production. B cells are a lymphocyte subset that repels foreign pathogens and controls endogenous commensal microbes by producing antibodies, also termed immunoglobulins (Igs). We are especially interested in a process called Ig heavy chain class switching. By replacing IgM with IgD, IgG, IgA or IgE, class switching provides antibodies with novel effector functions without changing their antigen specificity. In general, our goal is to dissect the mechanisms by which different subsets of systemic and mucosal B cells regulate class switching and antibody production during humoral responses to commensal or pathogenic microbes. We are also interested in the clonal architecture of these B cell responses.

 Research group

Members

Giuliana Magri (Researcher)

Roser Tachó Piñot (Technician)

Sonia Tejedor Vaquero (Technician)

​Main PublicationsOngoing Research ProjectsAppointmentsOutreach

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Main Publications

• Galindo-Campos MA, Bedora-Faure M, Farrés J, Lescale C, Moreno-Lama L, Martínez C, Martín-Caballero J, Ampurdanés C, Aparicio P, Dantzer F, Cerutti A, Deriano L, Yélamos J. 2019, Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promote B-cell development and function. Cell Death and Differ 2019 Dec; 26 (12): 2667-2268. IF 8.086. D1.

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Ongoing Research Projects

• Gut plasma cell responses in health and IBD (Retos grant)

- Financing institution: Ministerio de Educación y Ciencia (RTI2018-093894-B-I00)

- Period: from 2018 to 2021

- Principal investigator: Cerutti, Andrea

• Humoral responses in the respiratory mucosa: role of IgD

- Financing institution: Ministerio de Educación y Ciencia (SAF2014-52483R)

- Period: from 2015 to 2019

- Principal investigator: Cerutti, Andrea

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Appointments

• Andrea Cerutti. Member of the ERC Consolidator Grant Evaluation 2019, Panel LS6. European Research Council. 14-16/05/19 (Step 1).

• Andrea Cerutti. Member of the ERC Consolidator Grant Evaluation 2019, Panel LS6. European Research Council. 08-10/10/19 (Step 2).

 

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Outreach

Conferences, Seminars and Courses

• Andrea Cerutti. Invited speaker. Marginal Zone Lymphoma Scientific Workshop. New York (NY), 17-18 April 2019.

• Andrea Cerutti. Invited speaker. Immunology Seminar Series at the Kennedy Institute of Oxford University. Oxford (UK), 24 February 2019.

• Giuliana Magri. Invited speaker. Immunology Seminar Series. Manchester (UK), 28 February 2019.

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C/ Doctor Aiguader, 88

08003 Barcelona

(+34) 93 316 04 00

info@imim.es