2016
Group Leader
Francesc Xavier Nogués Solan
Our group’s research is about the study of bone mineral metabolism in patients with osteoporosis and other diseases related with bone loss. There are three strong lines of investigation in the Unit: Genetics, Epidemiology and Bone quality. The study of polymorphisms of genes related with bone and osteoporosis, functional analysis and association studies are the milestones of Genetics. BARCOS and B-ABLE are two cohorts of patients currently involved in ongoing studies related with bone health. Our group is co-investigator in the development of a novel, hand-held Reference Point Indentation (RPI) instrument, Osteoprobe®, that measures how well the bone of living patients resists indentation. Epidemiological local and international studies are developed also in our Unit.
Members
Isabel Aymar Fabrega (Technician)
Maria Lourdes Cos Esquius (Technician)
Elisabeth del Amo LaForga (Researcher)
Adolf Díez Pérez (Researcher)
Natalia García Giralt (Researcher)
Arturo Garrido Saldaña (Researcher)
Leonardo Mellibovsky Saidler (Researcher)
Marta Pineda Moncusí (Technician)
Daniel Prieto Alhambra (Researcher)
Jaime Rodríguez Morera (Technician)
Guillem Saló Bru (Researcher)
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Main Publications
• Abrahamsen B, Prieto-Alhambra D. Patients with Atypical Femur Fractures have the Same Mortality as the Background Population - Drug-Channelling Bias, Bisphosphonate Effects and Public Health Implications. J Bone Miner Res 2016; 31(3): 488-490. IF 5.622. Q1.
• Compston JE, Wyman A, Fitzgerald G, Adachi JD, Chapurlat RD, Cooper C, Díez-Pérez A, Gehlbach SH, Greenspan SL, Hooven FH, LaCroix AZ, March L, Netelenbos JC, Nieves JW, Pfeilschifter J, Rossini M, Roux C, Saag KG, Siris ES, Silverman S, Watts NB, Anderson Jr FA. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res 2016; 31(7): 1466-1472. IF 5.622. Q1.
• Hawley S, Javaid MK, Rubin KH, Judge A, Arden NK, Vestergaard P, Eastell R, Díez-Pérez A, Cooper C, Abrahamsen B, Prieto-Alhambra D. Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study. J Bone Miner Res 2016; 31(1): 234-244. IF 5.622. Q1.
• Hawley S, Leal J, Delmestri A, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A, and for REFReSH Study Group. Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis. J Bone Miner Res 2016; 31(11): 2008-2015. IF 5.622. Q1.
• Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study. Arthritis Rheumatol 2016; 68(8): 1869-1875. IF 6.009. Q1.
• Rodríguez-Sanz M, Pineda-Moncusí M, Servitja S, García-Giralt N, Tamara M, Tusquets I, María MG, Rodriguez-Morera J, Díez-Pérez A, Albanell J, Nogués X. TBS and BMD at the end of AI-therapy: A prospective study of the B-ABLE cohort. Bone 2016; 92:1-8. IF 4.14. Q1.
• Rodríguez-Sanz M, Prieto-Alhambra D, Servitja S, García-Giralt N, Garrigós L, Rodríguez-Morera J, Albanell J, Martínez-García M, González I, Díez-Pérez A, Tusquets I, Nogués X. AI-related BMD variation in actual practice conditions: a prospective cohort study. Endocr Relat Cancer 2016; 23(4): 303-312. IF 4.472. Q1.
Ongoing Research Projects
• Determinantes clínicos y genéticos de eventos musculoesqueléticos en mujeres posmenopáusicas tratadas con inhibidores de la aromatasa por cáncer de mama. Cohorte prospectiva B-ABLE
− Fondo de Investigación Sanitaria. ISCIII (PI13/00444)
− From 2014 to 2017
− Principal investigator: Nogués Solan, Francesc Xavier
• Identificación de dianas terapéuticas para la formación ósea: regulación de la expresión génica por microRNAs
− Fondo de Investigación Sanitaria. ISCIII (PI13/00116)
− From 2014 to 2016
− Principal investigator: Díez Pérez, Adolf
• Riesgo-beneficio de los bisfosfonatos en los pacientes con osteoporosis e insuficiencia renal
− Fondo de Investigación Sanitaria. ISCIII (ICI14/00248)
− From 2015 to 2017
− Principal investigator: Díez Pérez, Adolf
Participation in Research Networks
• Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad
− Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS. RD12/0043/0022
− Principal investigator: Díez Pérez, Adolf
• CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Barcelona, Spain
− Principal investigator: Díez Pérez, Adolf
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Unitat de Recerca en Fisiopatologia Òssia i Articular (2014-2017)
− Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 775)
− Principal investigator: Nogués Solan, Francesc Xavier
Theses
• De Ugarte, L. The regulatory roles of micrornas in bone remodeling and osteoporosis. Pompeu Fabra University
− Directors: García Giralt, Natalia; Díez Pérez, Adolf
− Date of defense: 18/11/2016
• Pérez Sáez, MJ. Enfermedad ósea en el paciente renal: avances epidemiológicos y diagnósticos. Autonomous University of Barcelona
− Directors: Pascual Santos, Julio; Díez Pérez, Adolf
− Date of defense: 16/12/2016
• Rodríguez-Sanz, M. Musculoskeletal side effects of aromatase inhibitors treatment in women with breast cancer. Pompeu Fabra University
− Directors: García Giralt, Natalia; Nogués Solan, Xavier
− Date of defense: 16/12/2016
• Carbonell, C. Tratamiento hospitalario de la fractura de fémur en España: variabilidad y tendencias. Autonomous University of Barcelona
− Directors: Prieto Alhambra, Daniel; Nogués Solan, Xavier
− Date of defense: 22/09/2016
• Zwart Salmeron, Marta. Estudis de cohorts per validar un model de categorització del risc de fractura per fragilitat en població femenina espanyola en base a l'algoritme frax de la oms. les cohorts FRIDEX i FROCAT. University of Barcelona
− Director: Díez Pérez, Adolf
− Date of defense: 2016
• Garcia-Gibert L. Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario. Universitat Autònoma de Barcelona
− Director: Nogués Solan, Xavier
− Date of defense: 13/07/2016
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08003 Barcelona
(+34) 93 316 04 00
info@imim.es