2016
Group Leader
Lluís Espinosa Blay
The Molecular Mechanisms of Cancer and Stemness group is fully dedicated to the identification of elements and pathways that regulate Stem Cell and Cancer Stem Cell homeostasis, with the final goal of discovering biomarkers and therapeutic targets for regenerative medicine and cancer.
The group has historically focused on studying the Notch and NF-κB pathways, which are principal actors of these processes. However, our research now aims to integrate these pathways in the context of other important signals for stem cell and cell transformation such as BRAF or ß-catenin.
Members
Carlota Colomer Montañá (PhD Student)
Jèssica González Miranda (Technician)
Laura Marruecos Aylagas (PhD Student)
Anna Vert Company (Researcher)
more info
Main Publications
• Gekas C, D'Altri T, Aligué R, González J, Espinosa L, Bigas A. Beta-Catenin is required for T cell leukemia initiation and MYC transcription downstream of Notch1. Leukemia 2016; 30(10): 2002-2010. IF 12.104. Q1.
Ongoing Research Projects
• Nuclear active IKKa as biomarker and new therapeutic target for Colorectal Cancer
− Fundació la Marató de TV3 (20131210)
− From 2014 to 2017
− Principal investigator: Espinosa Blay, Lluís
• Caracterización de phospho-sumo-IkBa y p45-IKKa como biomarcadores y posibles dianas terapéuticas en cáncer
− Fondo de Investigación Sanitaria. ISCIII (PI13/00448)
− From 2014 to 2016
− Principal investigator: Espinosa Blay, Lluís
Theses
• López-Arribillaga E. Notch signalling in intestinal homeostasis and cancer: orchestrator of stemness. Pompeu Fabra University
− Director: Espinosa Blay, Lluís; Bigas Salvans, Anna
− Date of defense: 17/06/2016
Patents
• Espinosa LL, Salvans A, López E, Gallardo F, Pujol RM. Therapeutic approaches to càncer.
− Application No: EP16382449.3
− Date: 30/09/2016
− Applicant: Fundació Institut Mar d’Investigacions Mèdiques i Fundació Balmes
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08003 Barcelona
(+34) 93 316 04 00
info@imim.es