2016
Group Leader
Ricard Solà Lamoglia
Since 2000, our work group has followed various lines of clinical research: The natural history of decompensated cirrhosis, ascites, renal insufficiency and infections; The virological response and viral kinetics during hepatitis C treatment in patients with or without HIV coinfection; The adherence to hepatitis C treatment and the study, prevention and treatment of the psychiatric pathology associated with the interferon and the progression of fibrosis in Hepatitis C with or without HIV coinfection. Recently we also have initiated diferent studies in Hepatitis B (particularly adherence to the treatment and reactivation, treatment and predictors of curation), hepatocellular carcinoma (natural history and impact of different etiologies) and non-alcoholic steatohepatitis (NASH).
Members
Maria Teresa Broquetas González (PhD Student)
José Antonio Carrión Rodríguez (Researcher)
Susana Coll Estrada (PhD Student)
Montserrat García Retortillo (Researcher)
Maria Dolors Giménez Romani (Technician)
Diego Lázaro Agudo (Research Assistant)
África Martínez Expósito (Technician)
Marc Puigvehí Badosa (PhD Student)
more info
Main Publications
• Gambato M, Caro-Pérez N, González P, Cañete N, Mariño Z, Lens S, Bonacci M, Bartres C, Sánchez-Tapias JM, Carrión JA, Forns X, Juan M, Pérez-Del-Pulgar S, Londoño MC. Neutrophil and Monocyte Function in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy with Regimens Containing Protease Inhibitors with and without Interferon. PLoS ONE 2016; 11(11): e0166631. IF 3.057. Q1.
• Lens S, Torres F, Puigvehí M, Mariño Z, Londoño MC, Martínez SM, García-Juárez I, García-Criado A, Gilabert R, Bru C, Solà R, Sánchez-Tapias JM, Carrión JA, Forns X. Predicting the development of liver cirrhosis by simple modelling in patients with chronic hepatitis C. Aliment Pharm Therap 2016; 43(3): 364-374. IF 6.32. Q1.
• Poca M, Alvarado-Tapias E, Concepción M, Pérez-Cameo C, Cañete N, Gich I, Romero C, Casas M, Román E, Castells L, Vargas V, Carrión JA, Guarner C, Soriano G. Predictive model of mortality in patients with spontaneous bacterial peritonitis. Aliment Pharm Therap 2016; 44(6): 629-637. IF 6.32. Q1.
• Puigvehí M, Hernández J, Broquetas M, Coll S, García-Retortillo M, Cañete N, Giménez MD, García-García M, Bory F, Salvadó M, Solà R, Carrión JA. Diagnostic Accuracy of the Enhanced Liver Fibrosis (ELF®) Score Using HCV-Infected Serum Samples Cryopreserved for up to 25 Years. PLoS ONE 2016; 11(12): e0164883. IF 3.057. Q1.
• Rodríguez-Nóvoa S, García-Samaniego J, Prieto M, Calleja JL, Pascasio JM, Delgado Blanco M, Crespo J, Buti M, Bonet Vidal ML, Arenas Ruiz Tapiador J, Fernández-Rodríguez C, Solá R, Fraga E, González Diéguez L, Núñez O, Praga M, Del Pino-Montes J, Romero-Gómez M, Morillas R, Diago M, Castro Á; MENTE Study Group. Altered Underlying Renal Tubular Function in Patients With Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in a Real-World Setting: The MENTE Study. J Clin Gastroenterol. 2016 Oct; 50(9): 779-89. IF 3.163. Q2.
• Udina M, Navinés R, Egmond E, Oriolo G, Langohr K, Giménez D, Valdés M, Gómez-Gil E, Grande I, Gratacòs M, Kapczinski F, Artigas F, Vieta E, Solà R, Martín-Santos R. Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression. Int J Neuropsychop 2016; 19(4): pyv135. IF 4.333. Q1.
Ongoing Research Projects
• Cuantificación del HBsAg en pacientes con Hepatitis B HBeAg-negativo, portadores inactivos o en tratamiento, para predecir la pérdida del HBsAg y correlación con los marcadores de fibrosis
− Fondo de Investigación Sanitaria. ISCIII (PI14/00540)
− From 2015 to 2017
− Principal investigator: Carrión Rodríguez, José Antonio
Clinical Trials Signed in 2016
• Estudio de fase II, abierto, multicéntrico, aleatorizado para evaluar la eficacia y seguridad de la combinación a dosis fija (CDF) de sofosbuvir/velpatasvir y la CDF de sofosbuvir/velpatasvir más ribavirina en pacientes con infección crónica por el VHC de genotipo 3 y cirrosis
− Register: GS-US-342-2097
− Principal investigator: Carrión Rodríguez, José Antonio
• Evidencia en Vida Real de la efectividad de Paritaprevir/r/Ombitasvir ± Dasabuvir (REGIMEN ABBVIE) ± Ribavirina en pacientes con Hepatitis C Crónica - Estudio Observacional Retrospectivo en España
− Register: ABB-OMB-2016-01
− Principal investigator: Carrión Rodríguez, José Antonio
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es