2016
Group Leader
Manuel Ramón Pera Román
The sequential process prior to the appearance of a gastric or esophageal adenocarcinoma is a sequential histologically well-defined process characterized by the appearance of an intestinal phenotype. In the first stages of gastro-esophageal carcinogenesis the expression of intestinal markers, as intestinal transcription factors (CDX2), mucin genes (MUC2 an MUC4), intestinal enzymes and others, can be detected. We study the molecular mechanisms that can be initiating these processes, through the regulation of transcription factors inducing the acquisition of the intestinal phenotype. In the esophagus, the development of columnar metaplasia (Barrett’s esophagus) is a response to a chronic gastroesophageal reflux injury and is a major risk factor for esophageal adenocarcinoma. Patients undergoing esophagectomy with a gastric conduit reconstruction develop columnar metaplasia in the remnant esophagus on a background of significant reflux, providing a useful model to study the early molecular events in the development of Barrett’s esophagus. miRNAs expression profiles may identify a characteristic signature that could distinguish between normal squamous epithelium, esophagitis, cardiac-type epithelium, and intestinal metaplasia. A group of miRNAs may selectively target specific transcriptional factors (CDX2) involved in the Barrett’s development.
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Main Publications
• Balmaña M, Giménez E, Puerta A, Llop E, Figueras J, Fort E, Sanz-Nebot V, de Bolós C, Rizzi A, Barrabés S, de Frutos M, Peracaula R. Increased α1-3-acid glycoprotein (AGP) in pancreatic cancer. J Proteomics 2016; 132: 144-154. IF 3.867. Q1.
• Climent M, Hidalgo N, Vidal O, Puig S, Iglesias M, Cuatrecasas M, Ramon-Moros JM, Garcia-Albeniz X, Grande L, Pera MR. Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer. Eur J Surg Oncol 2016; 42(1): 132-139. IF 2.94. Q1.
• Messager M, de Steur WO, Boelens PG, Jensen LS, Mariette C, Reynolds JV, Osorio J, Pera MR, Johansson J, Kolodziejczyk P, Roviello F, De Manzoni, Mönig SP, Allum WH, The EURECCA Upper GI group (European Registration of Cancer Care). Description and analysis of clinical pathways for oesophago-gastric adenocarcinoma, in 10 European countries (the EURECCA upper gastro intestinal group - European Registration of Cancer Care). Eur J Surg Oncol 2016; 42(9): 1432-1447. IF 2.94. Q1.
• Messager M, de Steur WO, van Sandick JW, Reynolds J, Pera MR, Mariette C, Hardwick RH, Bastiaannet E, Boelens PG, van de Velde CJ, Allum WH, The EURECCA Upper GI Group. Variations among 5 European countries for curative treatment of resectable oesophageal and gastric cancer: A survey from the EURECCA Upper GI Group (EUropean REgistration of Cancer CAre). Eur J Surg Oncol 2016; 42(1): 116-122. IF 2.94. Q1.
• Rice TW, Apperson-Hansen C, DiPaola LM, Semple ME, Lerut TEMR, Orringer MB, Chen LQ, Hofstetter W, Smithers M, Rizk NP, Wijhoven BPL, Chen K, Allum WH, D'Journo BX, Kesler KA, Luketich JD, Ferguson MK, Salo JA, van Hillegersberg R, Fang W, Durand L, Cecconello I, Cerfolio RJ, Pera M, Griffin SM, Burger R, Liu J-F, Allen MS, Law S, Watson TJ, Darling GE, Scott WJ, Duranceau A, Denlinger CE, Schipper PH, Ishwaran H, Blackstone EH. Worldwide Esophageal Cancer Collaboration: Clinical Staging Data. Dis Esophagus 2016; 29:707-714. IF 2.146. Q2.
Ongoing Research Projects
• Regulación de CDX2 por miRNAs durante el proceso de intestinalización de la metaplasia cardial en un modelo humano de esófago de Barrett
− Fondo de Investigación Sanitaria. ISCIII (PI13/00989)
− From 2014 to 2017
− Principal investigator: Pera Román, Manuel
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca en Carcinogènesi Gastroesofàgica (2014-2017)
− Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 602)
− Principal investigator: De Bolós Pi, Carme
Other
• Society Director, International Society for Diseases of the Esophagus (ISDE)
• Member, Scientific Committee, Spanish Association of Surgeons
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