Group Leader
Joan Ramon Masclans Enviz
The Critical Illness Research Group (GREPAC) aims at contributing to elucidate the mechanism involved in the onset and progression of different illnesses that cause a reversible dysfunction to one or more organs placing the patient’s life at risk. To do this, our research includes clinical research on patients, and also experimental models. These models allow us to study the molecular mechanisms involved in these processes and to identify therapeutic targets and new strategies against these illnesses and, whenever possible, to anticipate ourselves to these cascades to avoid more illnesses and multi-organ dysfunction.
The Critical Illness Research Group conceived Intensive Medicine research from a translational, clinical and multi-disciplinary approach; hence, another important objective is to further study new strategies and treatments by conducting controlled clinical trials and observational projects with a high interest, participating at all possible levels of commitment: as promoters, lead researchers, collaborators in multi-center projects and developing our own projects.
Members
Francisco Álvarez Lerma (Research)
Yolanda Díaz Buendía (Researcher)
Irene Dot Jordana (Researcher)
Marta Gas Amat (Research Assistant)
Maria Pilar Gracia Arnillas (Researcher)
Judith Marín Corral (Researcher)
Joan Nolla Salas (Researcher)
Purificación Pérez Terán (Researcher)
Antonia Vázquez Sánchez (Researcher)
Ana Zapatero Ferrándiz (Researcher)
more info
Main Publications
• Abdul-Aziz MH, Lipman J, Akova M, Bassetti M, De Waele J, Dimopoulos G, Dulhunty J, Kaukonen KM, Koulenti D, Martín C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Roberts JA, on behalf of the DALI Study Group (...Álvarez-Lerma F...). Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort. J Antimicrob Chemother 2016; 71(1): 196-207. IF 4.919. Q1.
• Álvarez-Lerma F, Marín J, Vila C, Masclans JR, González de Molina FJ, Martín Loeches, Barbadillo S, Rodríguez A, H1N1 GETGAG/SEMICYUC Study Group (...Vázquez-Sánchez A, Nolla-Salas J...). Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome. Crit Care 2016; 20(1): 337. IF 4.95. Q1.
• Barreiro E, Puig-Vilanova E, Marín J, Chacón-Cabrera A, Salazar-Degracia A, Mateu X, Puente-Maestu L, García-Arumí E, Andreu AL, Molina L. Therapeutic Approaches in Mitochondrial Dysfunction, Proteolysis, and Structural Alterations of Diaphragm and Gastrocnemius in Rats With Chronic Heart Failure. J Cell Physiol 2016; 231(7): 1495-1513. IF 4.155. Q1.
• Grau S, Luque S, Echeverría-Esnal D, Sorli L, Campillo N, Montero M, Álvarez-Lerma F, Plasencia V, Horcajada JP. Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp. Int J Antimicrob Ag 2016; 48(2): 212-214. IF 4.097. Q1.
• Pérez-Terán P, Roca O, Rodríguez-Palomares J, Ruiz-Rodríguez JC, Zapatero A, Gea J, Serra J, Evangelista A, Masclans JR. Prospective validation of right ventricular role in primary graft dysfunction after lung transplantation. Eur Respir J 2016; 48(6): 1732-1742. IF 8.332. Q1.
• Roca O, Hernández G, Díaz-Lobato S, Carratalá JM, Gutiérrez RM, Masclans JR, Spanish Multidisciplinary Group of High Flow Supportive Therapy in Adults (HiSpaFlow). Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure. Crit Care 2016; 20(1): 109. IF 4.95. Q1.
• Rodríguez AH, Avilés FX, Díaz E, Schuetz P, Trefler S, Cordero L, Vidaur L, Estella A, Pozo-Laderas JC, Socias L, Vergara JC, Zaragoza R, Bonastre J, Guerrero JE, Suberviola B, Cilloniz C, Restrepo MI, Martín-Loeches I, on behalf of the SEMICYUC/GETGAG Working Group (...Álvarez-Lerma F, Vázquez-Sánchez A, Nolla-Salas J...). Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis. J Infection 2016; 72(2): 143-151. IF 4.382. Q1.
• Ruiz-Castilla M, Roca O, Masclans JR, Barret JP. Recent advances in biomarkers in severe burns. Shock 2016; 45(2): 117-125. IF 3.048. Q1.
• Wolkewitz M, Cooper BS, Palomar-Martínez M, Álvarez-Lerma F, Olaechea-Astigarraga P, Barnett AG, Schumacher M. Multiple time scales in modeling the incidence of infections acquired in intensive care units. BMC Med Res Method 2016; 16: 116. IF 3.059. Q1.
• Wolkewitz M, Palomar-Martínez M, Olaechea PM, Álvarez-Lerma F, Schumacher M. A full competing risk analysis of hospital-acquired infections could easily be performed by a case-cohort approach. J Clin Epidemiol 2016; 74: 187-193. IF 4.703. Q1.
Ongoing Research Projects
• Papel del eje IL-33 /ST2 en el diagnóstico, pronóstico y tratamiento del Síndrome de distrés respiratorio agudo
− Fondo de Investigación Sanitaria. ISCIII (PI14/01420)
− From 2015 to 2017
− Principal investigator: Masclans Enviz, Joan Ramon
• Papel del eje IL-33 /ST2 en el diagnóstico, pronóstico y tratamiento del Síndrome de distrés respiratorio agudo
− Fundación Española de Enfermo Crítico
− From 2015 to 2017
− Principal investigator: Marín Corral, Judith
Participation in Research Networks
We have create and liderate a catalan critical care network on Acute Respiratory Distress Syndrome (ARDS), involving Vall d’Hebron University Hospital, Bellvitge University Hospital, Joan XXIII University Hospital (Tarragona) and our Center.
Clinical Trials Signed in 2016
• Agents Intervening against Delirium in Intensive Care Unit (AID-ICU): An international inception cohort study
− Register: CEIC 2016/6599
− Principal investigator: Marín Corral, Judith
• Estudio global fase II, aleatorizado para evaluar la eficacia y seguridad de Danirixin (GSK1325756) coadministrado con el antiviral estándar de tratamiento (oseltamivir), en el tratamiento de adultos hospitalizados con gripe
− Register: 201023
− Principal investigator: Álvarez Lerma, Francisco
Theses
• Pérez-Terán P. Ventrículo derecho y disfunción primaria del injerto en el trasplante pulmonar. Autonomous University of Barcelona
− Directors: Masclans, Joan Ramon; Serra, J; Evangelista, A
− Date of defense: 25/10/2016
• Gracia-Arnillas MP. Predicción de mortalidad del paciente ingresado en UCI: Desarrollo y validación de un nuevo modelo pronóstico. Autonomous University of Barcelona
− Director: Álvarez Lerma, Francisco
− Date of defense: 21/10/2016
Other
• Joan Ramon Masclans. President of the Catalan Critical Care Society Scientific Committee