2016
Group Leader
Sandra Peiró Sales
The group’s main research objective is focused on the characterization of chromatin dynamics and epigenetics in cancer and in epithelial-tomesenchymal transition (EMT). Our hypothesis is that during tumour progression and acquisition of malignant traits, global epigenetic changes together with high-order chromatin reorganization occurs to convert a noninvasive cell with the same DNA sequence in a more malignant and invasive cancer cell, which behaves completely different in the same biological environment. Large-scale mapping of genome-related parameters and their comparison is a logical and necessary next step in the exploration of genomes to understand how they are converted into malignant cells.
Members
Joan Pau Cebrià Costa (PhD Student)
Ane Iturbide Martínez de Albéniz (Technician)
Laura Pascual Reguant (Researcher)
Jèssica Querol Paños (Technician)
Main Publications
• Frigola J, Iturbide A, López-Bigas N, Peiró S, González-Pérez A. Altered oncomodules underlie chromatin regulatory factors driver mutations. Oncotarget 2016; 7(21): 30748-30759. IF 5.008. Q1.
• Herranz N, Dave N, Millanes-Romero A, Pascual-Reguant L, Morey L, Díaz VM, Lórenz-Fonfría V, Gutiérrez-Gallego R, Jeronimo C, Iturbide A, di Croce L, García de Herreros A, Peiró S. Lysyl Oxidase-Like 2 (LOXL2) Oxidizes Trimethylated Lysine 4 in Histone H3. FEBS J 2016; 283(23): 4263-4273. IF 4.237. Q1.
Ongoing Research Projects
• Finding the “readers” of oxidized histone H3 and new histone oxidases
− Fundació La Marató de TV3 (20132410)
− From 2014 to 2017
− Principal investigator: Peiró Sales, Sandra
• Chromatin Dynamics in EMT
− Fundación de Investigación Oncológica-FERO
− From 2014 to 2016
− Principal investigator: Peiró Sales, Sandra
• Heterochromatin reorganization during the EMT process is controlled by Snail1 transcription factor
− Worldwide Cancer Research-AICR (13-0094)
− From 2013 to 2016
− Principal investigator: Peiró Sales, Sandra
• Caracterización de la estructura tridimensional del genoma durante la transición epitelio-mesénquima
− Fondo de Investigación Sanitaria. ISCIII (PI15/00396)
− Principal investigator: Peiró Sales, Sandra
Theses
• Iturbide A. Identification of new LOXL2 substrates. A role for lysine oxidation in embryonic stem cell differentiation. Pompeu Fabra University
− Directors: Peiró Sales, Sandra; García de Herreros, Antonio
− Date of defense: 15/03/2016
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info@imim.es