Cardiovascular Epidemiology and Genetics

Research group

Group Leader

Roberto Elosua Llanos

The group is focused on the study of the epidemiology and the genetic basis of cardiovascular disorders and their risk factors. The research team involves a multidisciplinary group of epidemiologists, biologists, biochemists, clinicians and biostatisticians who work together to tackle these topics. The best-known study is the REGICOR project (REgistre GIroní del COR). The group is currently working in the estimation of the burden of cardiovascular disease at the population level; the development and improvement of the predictive capacity of cardiovascular risk functions; the analysis of trends in the clinical characteristics, management and prognosis of patients with myocardial infarction; the identification of the genetic architecture and of the epigenetics mechanisms related to coronary heart disease.

Members

Marta Cabañero Marimon (Technician)

Albert Clarà Velasco (Researcher)

Sandra Farré Anton (Research Assistant)

Yolanda Ferrer Campo (Research Assistant)

Leny Franco Rojas (Technician)

Sonia Gaixas Vasallo (Research Assistant)

Nadia García Mateo (Technician)

Esmeralda Gómez Pires (Research Assistant)

Maria Grau Magaña (Researcher)

Jaume Marrugat de la Iglesia (Researcher)

Silvia Pérez Fernández (Technician)

Irene Román Degano (Researcher)

Sergi Sayols Baixeras (PhD Student)

Isaac Subirana Cachinero (Technician)

Susanna Tello Rovira (Technician)

Joan Salvador Vila Domènech (Technician)

Maria del Mar Vila Muñoz (PhD Student)

 

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Main Publications

• Baena-Diez JM, Peñafiel J, Subirana I, Ramos R, Elosua R, Marin-Ibañez A, Guembe MJ, Rigo F, Tormo-Díaz MJ, Moreno-Iribas C, Cabré JJ, Segura A, García-Lareo M, Gómez de la Cámara A, Lapetra J, Quesada M, Marrugat J, Medrano MJ, Berjón J, Frontera G, Gavrila D, Barricarte A, Basora J, García J, Pavone NC, Lora-Pablos D, Mayoral E, Franch J, Mata M, Frances A, Grau M, on behalf of the FRESCO Investigators. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care 2016; 39(11): 1987-1995. IF 8.934. Q1.

• Di Cesare M, Bentham J, Stevens GA, Zhou B, Danaei G, Lu Y, Bixby H, Cowan MJ, Riley LM, Hajifathalian K, Fortunato L, Taddei C, Bennett JE, Ikeda N, Khang YH, Kyobutungi C, Laxmaiah A, Li Y, Lin HH, Miranda JJ, Mostafa A, Turley ML, Paciorek CJ, Gunter M, Ezzati M, NCD Risk Factor Collaboration (NCD-RisC) (...Marrugat J, Porta M...). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 2016; 387(10026): 1377-1396. IF 44.002. Q1.

• Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S, and the CHARGE–Heart Failure Consortium and CARDIoGRAM Exome Consortium. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol 2016; 68: 2761-2772. IF 17.759. Q1.

• Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 2016; 536(7616): 285-291. IF 38.138. Q1.

• Marrugat J, Elosua R, Grau M, Sayols-Baixeras S, Dégano IR. Prevalencia y pronóstico de los pacientes con infarto de miocardio de alto riesgo candidatos a doble tratamiento antiagregante prolongado. Rev Esp Cardiol 2016; 69(5): 480-487. IF 4.596. Q1.

• Ramos R, García-Gil M, Comas-Cufí M, Quesada M, Marrugat J, Elosua R, Grau M, Martí R, Ponjoan A, Alves-Cabratosa L, Blanch J, Bolíbar B. Statins for Prevention of Cardiovascular Events in a Low-Risk Population With Low Ankle Brachial Index. J Am Coll Cardiol 2016; 67(2): 630-40. IF 17.759. Q1.

• Sayols-Baixeras S, Subirana I, Lluis-Ganella C, Civeira F, Roquer J, Do AN, Absher D, Cenarro A, Muñoz D, Soriano-Tárraga C, Jiménez-Conde J, Ordovas JM, Senti M, Aslibekyan S, Marrugat J, Arnett DK, Elosua R. Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study. Hum Mol Genet. 2016 Oct 15; 25(20): 4556-4565. IF 5.985. Q1.

• Soriano C, Jiménez-Conde J, Giralt E, Mola M, Vivanco R, Ois A, Rodríguez-Campello A, Cuadrado E, Sayols-Baixeras S, Elosua R, Roquer J, on behalf of the GENESTROKE Consortium. Epigenome-wide association study identifies TXNIP gene associated with Type 2 diabetes mellitus and sustained hyperglycemia. Hum Mol Genet 2016; 25(3): 609-619. IF 5.985. Q1.

• Velescu A, Clará A, Peñafiel J, Grau M, Dégano IR, Martí R, Ramos R, Marrugat J, Elosua R. Peripheral Arterial Disease Incidence and Associated Risk Factors in a Mediterranean Population-based Cohort. The REGICOR Study. Eur J Vasc Endovasc Surg 2016; 51(5): 696-705. IF 2.912. Q1.

Ongoing Research Projects

• Role of micro RNAs expressed by human endothelial and vascular smooth muscle cells in myocardial infarction (MIRMID: micro RNAs in Myocardial Infarction Disease)

− Fundación BBVA (PR-16_BIO_CAR_0041)

− From 2016 to 2019

− Principal investigator: Marrugat de la Iglesia, Jaume

 

• La metilación del ADN y el infarto agudo de miocardio: ¿biomarcador de riesgo y mediador de los efectos de estilos de vida?

− Fondo de Investigación Sanitaria. ISCIII (PI15/00051)

− From 2016 to 2018

− Principal investigator: Elosua Llanos, Roberto

 

• Papel del microRNA no codificante producido por las células endoteliales y musculares lisas arteriales humanas en el infarto de miocardio

− Fondo de Investigación Sanitaria. ISCIII (PI15/00064)

− From 2016 to 2018

− Principal investigator: Marrugat de la Iglesia, Jaume

 

• Socioeconomic Status and Cardiovascular Health: Analysis of the Association and of the Mediating Mechanisms

− RECERCAIXA (RE087465)

− From 2015 to 2017

− Principal investigator: Elosua Llanos, Roberto

 

• Validez y efectividad de un método de auto-cribado del riesgo cardiovascular

− Fondo de Investigación Sanitaria. ISCIII (PI14/00449)

− From 2015 to 2017

− Principal investigator: Grau Magaña, María

 

• Burden of cardiovascular diseases associated with chronic inflammatory conditions: a population approach

− Fondo de Investigación Sanitaria. ISCIII (CP12/03287)

− From 2013 to 2017

− Principal investigator: Grau Magaña, María

Participation in Research Networks

• Red Cardiovascular

− Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS. RD12/0042/0061

− Principal investigator: Marrugat de la Iglesia, Jaume

 

• Red Cardiovascular

− Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS. RD12/0042/0013

− Principal investigator: Elosua Llanos, Roberto

Group’s Recognitions

• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de recerca consolidat Registre Gironí del Cor-REGICOR (2014-2017)

− Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 240)

− Principal investigator: Marrugat de la Iglesia, Jaume

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info@imim.es