Group Leader

Andrea Cerutti
(ICREA professor)

In the B Cell Biology research group we take advantage of different cellular, histological and molecular techniques to address basic questions related to the regulation of B cell activation and antibody production. B cells are a type of lymphocyte whose main function is to fight infections by producing antibodies. Our research group is especially interested in the immunoglobulin (Ig) class switching of the antibody heavy chains. By substituting IgM with IgG, IgA or IgE, class switching provides antibodies with novel effect or functions without changing their antigen specificity. Our overall goal is to dissect the mechanisms by which different subsets of systemic and mucosal B cells regulate class switching in response to signals from microbial products and innate immune cells.

Members

Sabrina Daniela Bascones Gleave (PhD Student)

Nerea Castro Rodríguez (Technician)

David Lligé Santafé (Technician)

Giuliana Magri (Researcher)

Marc Pybus Oliveras (Researcher)

Daniel Segura Garzón (Technician)

Jordi Sintes Castro (Researcher)

Ada Yeste Bornal (Technician)

 

more info

Main Publications

• Chorny A, Casas-Recasens S, Sintes J, Shan M, Polenta-rutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A. The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. J Exp Med. 2016 Sep 19; 213(10): 2167-85. Q1.

• Magri G, Cerutti A. A Touch of Youth in Gut Microbiota Development. Immunity 2016; 45: 12-14. IF 24.082. Q1.

• Mensa-Vilaró A, Bosque MT, Magri G, Honda Y, Martínez-Banaclocha H, Casorran-Bergés M, Sintes J, González-Roca E, Ruiz-Ortiz E, Heike T, Martínez-García JJ, Baroja-Mazo A, Cerutti A, Nishikomori R, Yagüe J, Pelegrín P, Delgado-Beltrán C, Aróstegui JI. Late onset cryopyrin-associated periodic syndrome due to myeloid-restricted somatic NLRP3 mosaicism. Arthritis Rheumatol 2016; 68(12): 3035-3041. IF 6.009. Q1.

Ongoing Research Projects

Estudio de la respuesta humoral en la mucosa respiratoria: papel de la IgD

− Ministerio de Economía y Competitividad (SAF2014-52483-R)

− From 2015 to 2017

− Principal investigator: Cerutti, Andrea

 

Innate Signalling Networks in B-Cell Antibody Production: New Targets for Vaccine Development (ERC GRANT)

− European Community (294561)

− From 2012 to 2017

− Principal investigator: Cerutti, Andrea

Group’s Recognitions

Officially recognized as a consolidated research group by the Generalitat de Catalunya: Grup de Biologia de les Cèl·lules B (2014-2017)

− Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 832)

− Principal investigator: Cerutti, Andrea

Theses

Comerma L. Identification and Characterization of a Novel Population of Memory B Cells in the Human Intestine. Pompeu Fabra University

− Directors: Cerutti, Andrea; Magri, Giuliana

− Date of defense: 12/07/2016

 

Bascones S. Role of Splenic Stromal Cells in Systemic Antibody Responses to Commensal Antigens. Pompeu Fabra University

− Director: Cerutti, Andrea; Sintes, Jordi

− Date of defense: 20/12/2016

C/ Doctor Aiguader, 88

08003 Barcelona

(+34) 93 316 04 00

info@imim.es