Epilepsy
Research group
Group Leader
Rodrigo Alberto Rocamora Zúñiga
The research of this group focuses primarily on cognitive aspects and their correlation with surgical and electrophysiological procedures, as well as the pharmacotherapy of epilepsy and genetic diagnosis. To facilitate this they have established collaborations with national and international centres, including the Epilepsy Centre at the University of Freiburg, the Bonn Epilepsy Surgery Centre, and the Grenoble Epilepsy Centre. Nationally, there is ongoing cooperation with the Centre for Brain and Cognition (CBC), The Synthetic Perceptive, Emotive and Cognitive Systems group (SPECS), and the Centre for Genomic Regulation (CRG) at Pompeu Fabra University (UPF).
The Epilepsy Unit primarily focuses its research on specific aspects of diagnosing the location of epileptic focus, as well as the electrophysiological and cognitive correlates of cerebral records obtained using invasive electrophysiological techniques. They have also undertaken research into clinical pharmacology and comorbidities associated with epilepsy, especially in the field of psychiatry, sleep disorders and sudden death in epilepsy.
Members
Gerard Conesa Bertran (Researcher)
Alessandro Principe (Researcher)
Carmen Pérez Enríquez (Technician)
Laura Serrano Pérez (Technician)
Main Publications
• Tauste A, Principe A, Ley M, Rocamora R, Deco G. Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain. PLoS Biol 2018; 16(4): e2002580. IF 9.163. D1.
• Cruzat J, Deco G, Tauste A, Principe A, Costa A, Kringelbach ML, Rocamora R. The dynamics of human cognition: Increasing global integration coupled with decreasing segregation found using iEEG. Neuroimage 2018; 172: 492-505. IF 5.426. D1.
• Principe A, Ley M, Conesa G, Rocamora R. Prediction error connectivity: A new method for EEG state analysis. Neuroimage 2018; 188: 261-273. IF 5.426. D1.
• Trebaul L, Deman P, Tuyisenge V, Jedynak M, Hugues E, Rudrauf D, Bhattacharjee M, Tadel F, Chanteloup-Foret B, Saubat C, et al. Probabilistic functional tractography of the human cortex revisited. Neuroimage 2018; 181: 414-429. IF 5.426. D1.
Ongoing Research Projects
• SYLVIUS: A novel multimodal integrative computer platform to model Language and improve neurosurgical planning and treatment outcome
- Financing institution: Fundació “La Caixa”
- Period: from 2014 to 2019
- Principal investigator: Conesa Bertran, Gerard
Group’s Recognitions
• Officially recognised as an emerging research group by the Generalitat de Catalunya: Grup d’Epilèpsia (GE) (2017-2020)
- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 455)
- Principal investigator: Principe, Alessandro
Clinical Trials Signed in 2018
• Estudio de dos partes de ZX008 en niños y adultos con síndrome de Lennox-Gastaut (LGS); Parte 1: Ensayo aleatorizado, con doble ciego y controlado con placebo de dos dosis fijas de solución oral de ZX008 (clorhidrato de fenfluramina) como tratamiento complementario para crisis epilépticas en niños y adultos con LGS, seguido de la Parte 2: Ampliación abierta para evaluar la seguridad a largo plazo del ZX008 en niños y adultos con LGS.
- Register: ZX008-1601
- Principal investigator: Rocamora Zúñiga, Rodrigo Alberto
• Estudio aleatorizado, doble ciego, controlado con placebo, de búsqueda de dosis para evaluar la eficacia y la seguridad de padsevonil como tratamiento adyuvante de crisis focales en sujetos adultos con epilepsia fármacorresistente
- Register: EP0091
- Principal investigator: Rocamora Zúñiga, Rodrigo Alberto
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es