B Cell Biology
Research group
In the B Cell Biology research group we take advantage of different cellular, histological and molecular techniques to address basic questions related to the regulation of B cell activation and antibody production. B cells are a type of lymphocyte whose main function is to fight infections by producing antibodies. Our research group is especially interested in the class switching of the immunglobulin (Ig) heavy chain. By substituting IgM with IgG, IgA or IgE, class switching provides antibodies with novel effector functions without changing their antigen specificity. Our overall goal is to dissect the mechanisms by which different subsets of systemic or mucosal B cells regulate class switching and antibody production in response to signals from microbial products and the innate immune system.
Members
Giuliana Magri (Researcher)
Sonia Tejedor Vaquero (Technician)
Roser Tachó Piñot (Technician)
Main Publications
• Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM. Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses. Immunity 2018; 48(3): 584-598. IF 19.734. D1.
• Shan M, Carrillo J, Yeste A, Gutzeit C, Segura D, Walland AC, Pybus M, Grasset EK, Yeiser JR, Matthews DB, van de Veen W, et al. Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44. Immunity 2018; 49(4): 709-724.e8. IF 19.734. D1.
• Farinello D, Wozinska M, Lenti E, Genovese L, Bianchessi S, Migliori E, Sacchetti N, di Lillo A, Bertilaccio MTS, de Lalla C, et al. A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression. Nat Commun 2018; 9(1): 1787. IF 12.353. D1.
• García-Carmona Y, Ting AT, Radigan L, Athuluri Divakar SK, Chávez J, Meffre E, Cerutti A, Cunningham-Rundles C. TACI Isoforms Regulate Ligand Binding and Receptor Function. Front Immunol 2018; 9: 2125. IF 5.511. Q1.
• Pizzagalli DU, Farsakoglu Y, Palomino-Segura M, Palladino E, Sintes J, Marangoni F, Mempel TR, Koh WH, Murooka TT, Thelen F, Stein JV, Pozzi G, Thelen M, Krause R, González SF. Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos. Sci Data 2018; 5: 180129. IF 5.305. Q1.
Ongoing Research Projects
• Estudio de la respuesta humoral en la mucosa respiratoria: papel de la IgD
- Financing institution: Ministerio de Economía y Competitividad (SAF2014-52483-R)
- Period: from 2015 to 2019
- Principal investigator: Cerutti, Andrea
• Innate Signalling Networks in B-Cell Antibody Production: New Targets for Vaccine Development (ERC GRANT)
- Financing institution: European Community (294561)
- Period: from 2012 to 2018
- Principal investigator: Cerutti, Andrea
Group’s Recognitions
• Officially recognized as a consolidated research group by the Generalitat de Catalunya: B cell biology group (2017-2020)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 120)
- Principal investigator: Cerutti, Andrea
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es