Stem Cells and Cancer

Research group

Group Leader

Anna Bigas Salvans

Our research group studies the molecular mechanisms involved in the generation and maintenance of stem cells and their differentiation from functional cells. We particularly focus in studying signaling pathways and their activation effects that control the hematopoietic system. Our goal is to understand how these signals are important in the generation of hematopoietic stem cells during embryonic development, maintenance of these cells in adulthood and how these signals are perturbed in leukemic processes.

2017

Members

Paolo Petazzi (Researcher)

Cristina Porcheri (Researcher)

David Arambilet Morilla (Technician)

Jessica González Miranda (Technician)

Neus Luque Sánchez (Technician)

Irene Pecharroman Ruiz (Technician)

Cristina Ruiz Herguido (Technician)

Main Publications

• Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell 2017; 32(5): 608-623. IF 27.407. D1.

• Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Mol Cell 2017; 68(4): 645-658. IF 14.714. D1.

• Perearnau A, Orlando S, Islam AB, Gallastegui E, Martínez J, Jordan A, Bigas A, Aligué R, Pujol MJ, Bachs O. P27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes. Nucleic Acids Res 2017; 45(9): 5086-5099. IF 10.162. D1.

Ongoing Research Projects

• Regeneració hematopoètica a partir de cèl·lules mare pluripotents

- Departament de Salut, Generalitat de Catalunya (SLT002/16/00299)

- From 2017 to 2019