Poly (ADP-ribose) Polymerases
Research group
Group Leader
José Yélamos López
The aim of this group is to investigate the role of poly(ADP-ribosyl)ation of nuclear proteins, catalysed by PARP family members (specially PARP-1 and PARP-2), as a critical signaling pathway at nuclear level, in both innate and acquire immune response. The results from this study could allow identifying new therapeutic target in different pathophysiological conditions associated with the immune system.
Members
Jaime Jimeno Fraile (Researcher)
Coral Ampurdanés Descals (Technician)
Lucia Moreno Lama (Technician)
Main Publications
• Giménez-Arnau AM, Curto-Barredo L, Nonell L, Puigdecanet E, Yélamos J, Gimeno R, Rüberg S, Santamaria-Babí L, Pujol RM. Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement. Allergy 2017; 72(11): 1778-1790. IF 7.361. D1.
• López-Botet M, Vilches C, Redondo D, Muntasell A, Pupuleku A, Yélamos J, Pascual J, Crespo M. Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation. Front Immunol 2017; 8: 166. IF 6.429. Q1.
• Yélamos J. ATM/MAPK7 crosstalk in cancer (Editorial). Oncotarget 2017; 8(9): 14271-14272. IF 5.168. Q1.
• Redondo D, Crespo M, Yélamos J, Muntasell A, Pérez-Sáez MJ, Vila JS, Vilches C, Pascual J, López-Botet M. Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients. J Immunol 2017; 198(1): 94-101. IF 4.856. Q1.
• Navarro J, Gozalbo-López B, Méndez AC, Dantzer F, Schreiber V, Martínez C, Arana DM, Farrés J, Revilla-Nuin B, Bueno MF, Ampurdanés C, Galindo-Campos MA, Knobel PA, Segura-Bayona S, Martin-Caballero J, Stracker TH, Aparicio P, Del Val M, Yélamos J. PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas. Sci Rep 2017; 7: 41962. IF 4.259. Q1.
• Chacón-Cabrera A, Mateu-Jiménez M, Langohr K, Fermoselle C, García-Arumí E, Andreu AL, Yélamos J, Barreiro E. Role of Parp Activity in Lung Cancer-induced Cachexia: Effects on Muscle Oxidative Stress, Proteolysis, Anabolic Markers and Phenotype. J Cell Physiol 2017; 232(12): 3744-3761. IF 4.08. Q1.
Ongoing Research Projects
• Modulación de la respuesta inmune por las proteínas PARP en cáncer de mama
- Fundación Associación Española Contra el Cáncer (1493)
- From 2017 to 2020
- Principal investigator: Yélamos López, José
• Estudio de la interacción entre rutas de señalización mediadas por Poli-ADP-ribosilación y fosforilación en la respuesta al daño en el DNA y sus implicaciones en cáncer
- Ministerio de Economía y Competitividad (SAF2014-53467-R)
- From 2015 to 2017
- Principal investigator: Yélamos López, José
• Exploring synthetic lethal interactions between PARP and the DNA damage response in cancer treatment
- Fundació La Marató de TV3 (20134130)
- From 2014 to 2017
- Principal investigator: Yélamos López, José
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Diferenciació i Fisiopatologia Limfocitària (2017-2019)
- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 125)
- Principal investigator: Yélamos López, José
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es