Neurovascular
Research group
Group Leader
Jaume Roquer González
This is a clinical group involved in stroke research. Currently our group is included in the Red de Enfermedades Vasculares Cerebrales (INVICTUS PLUS) that is one of the main Spanish research networks. The strengths of our group are: first, our ongoing database named BASICMAR, that contains extensive demographic, epidemiological, clinical, and outcome data about all stroke patients (n=7,700) admitted to our hospital, and second, our large collection of blood sample of stroke patients for genetic and biomarkers studies (n=5,000). The two main research lines are:
1. Clinical research and biomarkers in stroke: epidemiology, natural history and vascular risk factors, stroke biomarkers, environmental and stroke, diet and stroke, neurosonology and neuro-imaging.
2. Genetic and stroke research: our unit is part of the International Stroke Genetics Consortium, which includes many international (USA, Europe) and national groups and of the GENESTROKE Consortium working to develop GWAS and EWAS studies and projects.
Members
Eva Giralt Steinhauer (Researcher)
Jordi Jiménez Conde (Researcher)
Ángel Javier Ois Santiago (Researcher)
Ana María Rodríguez Campello (Researcher)
Carolina Soriano Tárraga (Researcher)
Elisa Cuadrado Godia (PhD Student)
Ane Miren Crespo Cuevas (Technician)
Marina Mola Caminal (Technician)
Albert Puig Pijoan (Technician)
Gemma Romeral Ballester (Technician)
Miguel Ángel Rubio Pérez (Technician)
Rosa Maria Vivanco Hidalgo (Technician)
Main Publications
• Phuah CL, Dave T, Malik R, Raffeld MR, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Jagiella JM, Hansen BM, Norrving B, Jiménez-Conde J, Roquer J, Pichler A, Enzinger C, Montaner J, Fernández-Cadenas I, Lindgren A, Slowik A, Schmidt R, Biffi A, Rost N, Langefeld CD, Markus HS, Mitchell BD, Worrall BB, Kittner SJ, Woo D, Dichgans M, Rosand J, Anderson CD, METASTROKE, NINDS-SiGN Consortium, International Stroke Genetics Consortium. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain 2017; 140(10): 2663-2672. IF 10.292. D1.
• Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT, Ikram MA, Launer LJ, et al. Genetic Variation at 16q24.2 is associated with small vessel stroke. Ann Neurol 2017; 81(3): 383-394. IF 9.89. D1.
• Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernández-Cadenas I, Jiménez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM, Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC). COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology 2017; 89(17): 1829-1839. IF 7.592. D1.
• Roquer J, Vivanco R, Ois A, Rodríguez-Campello A, Cuadrado E, Giralt E, Gómez-González A, Soriano C, Jiménez-Conde J. Antithrombotic pretreatment increases very-early mortality in primary intracerebral hemorrhage. Neurology 2017; 88(9): 885-891. IF 7.592. D1.
• Soriano C, Mola M, Giralt E, Ois A, Rodríguez-Campello A, Cuadrado E, Gómez-González A, Vivanco R, Fernández-Cadenas I, Cullell N, Roquer J, Jiménez-Conde J. Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke. Neurology 2017; 89(8): 830-836. IF 7.592. D1.
• Fernández-Cadenas I, Mendióroz M, Giralt D, Nafria C, García E, Carrera C, Gallego-Fabrega C, Domingues-Montanari S, Delgado P, Ribó M, Castellanos M, Martínez S, Freijo M, Jiménez-Conde J, Rubiera M, Álvarez-Sabín J, Molina CA, Font MA, Grau M, Palomeras E, Pérez de la Ossa N, Martínez-Zabaleta M, Masjuan J, Moniche F, Canovas D, Piñana C, Purroy F, Cocho D, Navas I, Tejero C, Aymerich N, Cullell N, Muiño E, Serena J, Rubio F, Dávalos A, Roquer J, Arenillas JF, Martí-Fábregas J, Keene K, Chen WM, Worrall B, Sale M, Arboix A, Krupinski J, Montaner J, GRECOS Study Group. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke. Stroke 2017; 48(5): 1147-1153. IF 6.032. D1.
• Purroy F, Vena A, Cánovas D, Cardona P, Cocho D, Cuadrado E, Chamorro A, Dávalos A, Garcés M, Gomis M, Krupinski J, Palomeras E, Ribó M, Roquer J, Rubiera M, Sanahuja J, Saura J, Serena J, Ustrell X, Vargas M, Benabdelhak I, Abilleira S, Gallofré M, Catalan Stroke Code and Reperfusion Consortium. Influence of Hospital Type on Outcomes of Individuals Aged 80 and Older with Stroke Treated Using Intravenous Thrombolysis. J Am Geriatr Soc 2017; 65(9): E117-E122. IF 4.388. D1.
• Giralt E, Ois A, Abilleira S, Urra X, Cardona-Portela P, Gomis M, Castellanos M, Molina C, Martí-Fàbregas J, Pellisé A, Cánovas D, Gómez-Choco M, Kuprinski J, Cocho D, Roquer J, and on behalf of the Cat-SCR Consortium. Frequency and outcome of total anterior circulation strokes without intracranial large-vessel occlusion. Eur J Neurol 2017; 24(1): 11-17. IF 3.988. Q1.
• Rodríguez-Campello A, Jiménez-Conde J, Ois A, Cuadrado E, Giralt E, Vivanco R, Soriano C, Subirana I, Muñoz D, Gómez-González A, Puig-Pijoan A, Roquer J. Sex-related differences in abdominal obesity impact on ischemic stroke risk. Eur J Neurol 2017; 24(2): 397-403. IF 3.988. Q1.
• Vivanco R, Elosua R, Gómez-González A, Moreira A, Díez L, Grau M, Dégano IR, Roquer J. People with epilepsy receive more statins than the general population but have no higher cardiovascular risk: results from a cross-sectional study. Eur J Neurol 2017; 24(2): 419-426. IF 3.988. Q1.
Ongoing Research Projects
• Impacto de la polución ambiental aérea (carbón negro y material particulado) en el ictus isquémico
- Fondo de Investigación Sanitaria. ISCIII (PI15/00445)
- From 2016 to 2018
- Principal investigator: Roquer González, Jaume
• Estudio de Epigenome Wide Association en Leucoaraiosis. Contribución de la epigenética en el envejecimiento cerebral. International Stroke Genetic Consortium (ISGC)
- Fondo de Investigación Sanitaria. ISCIII (PI15/00451)
- From 2016 to 2018
- Principal investigator: Jiménez Conde, Jordi
Participation in Research Networks
• Red de Enfermedades Vasculares Cerebrales. INVICTUS PLUS.
- Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS (RD16/0019/0002)
- Principal investigator: Roquer González, Jaume
Group’s Recognitions
• Officially recognized as a consolidated research group the Generalitat de Catalunya: Grup de Recerca Neurovascular (NEUVAS) (2017-2019)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 28)
- Principal investitgator: Roquer González, Jaume
Clinical Trials Signed in 2017
• Estudio de fase 2, controlado con placebo, aleatorizado, doble ciego y de grupos paralelos para evaluar la eficacia y la seguridad de BMS-986141 en la prevención del infarto cerebral recurrente en sujetos que reciben ácido acetilsalicílico (AAS) después de un ictus isquémico agudo o de un accidente isquémico transitorio
- Register: CV006-004
- Principal investigator: Roquer González, Jaume
• Estudio de dabigatrán en la fase temprana del ictus. Estudio de nuevos marcadores de neuroimagen y de biomarcadores (ESTUDIO SEDMAN)
- Register: JKB-DAB-2016-01
- Principal investigator: Jiménez Conde, Jordi
• Estudio no intervencionista sobre el tratamiento con edoxabán en la práctica clínica habitual para pacientes con fibrilación auricular no valvular
- Register: DSE-EDO-2016-01
- Principal investigator: Rodríguez Campello, Ana María
• CONVINCE (COlchicine for preventioN of Vascular Inflammation in Non- CardioEmbolic stroke): un ensayo clínico aleatorizado de la colchicina en dosis bajas para la prevención secundaria después de un accidente cerebrovascular
- Register: CONVINCE
- Principal investigator: Cuadrado Godia, Elisa
• Ensayo Fase III, aleatorizado, doble ciego, internacional, multicéntrico, controlado con placebo, para evaluar la eficacia y seguridad de ticagrelor y AAS, comparado con AAS en la prevención de ictus y muerte en pacientes con ictus isquémico agudo o accidente isquémico transitorio” (THALES)
- Register: D5134C00003
- Principal investigator: Roquer González, Jaume
Theses
• Vivanco R. Factors de risc i risc cardiovascular en els pacients amb epilèpsia. Autonomous University of Barcelona
- Director: Roquer González, Jaume
- Date of defense: 09/05/2017
• Mola M. Genetic contribution to functional Outcome and Disability after Stroke. University of Barcelona
- Director: Jiménez Conde, Jordi
- Date of defense: 18/07/2017
• Rodríguez-Campello A. Influencia de los hábitos dietéticos y de la obesidad abdominal en el ictus isquémico. Autonomous University of Barcelona
- Director: Roquer González, Jaume
- Date of defense: 24/01/2017
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es