Cardiovascular Epidemology and Genetics
Research group
Group Leader
Roberto Elosua Llanos
The group is focused on the study of the epidemiology and the genetic basis of cardiovascular disorders and their risk factors. The research team involves a multidisciplinary group of epidemiologists, biologists, biochemists, clinicians and biostatisticians who work together to tackle these topics. The best-known study is the REGICOR project (REgistre GIroní del COR). The group is currently working in the estimation of the burden of cardiovascular disease at the population level; the development and improvement of the predictive capacity of cardiovascular risk functions; the analysis of trends in the clinical characteristics, management and prognosis of patients with myocardial infarction; the identification of the genetic architecture and of the epigenetics mechanisms related to coronary heart disease.
Members
Albert Clarà Velasco (Researcher)
Maria Grau Magaña (Researcher)
Jaume Marrugat de la Iglesia (Researcher)
Albert Prats Uribe (Researcher)
Irene Roman Degano (Researcher)
Alina Velescu (Researcher)
Alba Fernández Sanlés (PhD Student)
Sergi Sayols Baixeras (PhD Student)
Maria del Mar Vila Muñoz (PhD Student)
Sandra Farré Anton (Research Assistant)
Yolanda Ferrer Campo (Research Assistant)
Sonia Gaixas Vasallo (Research Assistant)
Esmeralda Gómez Pires (Research Assistant)
Eric Brosa Marce (Technician)
Marta Cabañero Marimon (Technician)
Esther Cáceres Malagelada (Technician)
Margarita de la Iglesia del Águila (Technician)
Leny Franco Rojas (Technician)
Nadia García Mateo (Technician)
Luis Gavilán Téllez (Technician)
Ana Moreno Subirats (Technician)
Lidia Pérez Cuevas (Technician)
Silvia Pérez Fernández (Technician)
Juan Luis Seguí Taboada (Technician)
Isaac Subirana Cachinero (Technician)
Susanna Tello Rovira (Technician)
Joan Salvador Vila Domènech (Technician)
Main Publications
• NCD Risk Factor Collaboration (NCD-RisC) (...Elosua R, Marrugat J, Porta M...). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet 2017; 389(10064): 37-55. IF 47.831. D1.
• NCD Risk Factor Collaboration (NCD-RisC) (...Marrugat J, Porta M...). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet 2017; 390(10113): 2627-2642. IF 47.831. D1.
• Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S, Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA 2017; 317(9): 937-946. IF 44.405. D1.
• Fuks KB, Weinmayr G, Basagaña X, Gruzieva O, Hampel R, Oftedal B, Sørensen M, Wolf K, Aamodt G, Aasvang GM, Aguilera I, Becker T, Beelen R, Brunekreef B, Caracciolo B, Cyrys J, Elosua R, Eriksen KT, Foraster M, Fratiglioni L, Hilding A, Houthuijs D, Korek M, Künzli N, Marrugat J, Nieuwenhuijsen M, Östenson CG, Penell J, Pershagen G, Raaschou-Nielsen O, Swart WJR, Peters A, Hoffmann B. Long-term exposure to ambient air pollution and traffic noise and incident hypertension in seven cohorts of the European study of cohorts for air pollution effects (ESCAPE). Eur Heart J 2017; 38(13): 983-990. IF 19.651. D1.
• Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh JN, Ardissino D, Gabriel SB, Willer CJ, Abecasis G, Saleheen D, Kubo M, Kato N, Chen YI, Dewey F, Kathiresan S. Protein Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res 2017; 121(1): 81-88. IF 13.965. D1.
• Sayols-Baixeras S, Hernáez A, Subirana I, Lluís-Ganella C, Muñoz D, Fitó M, Marrugat J, Elosua R. DNA Methylation and High-Density Lipoprotein Functionality: The REGICOR Study. Arterioscler Thromb Vasc Biol 2017; 37(3): 567-569. IF 6.607. D1.
• Dégano IR, Subirana I, Fusco D, Tavazzi L, Kirchberger I, Farmakis D, Ferrières J, Azevedo A, Torre M, Garel P, Brosa M, Davoli M, Meisinger C, Bongard V, Araújo C, Lekakis J, Francés A, Castell C, Elosua R, Marrugat J, EUROTRACS investigators. Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease. Int J Cardiol 2017; 249: 83-89. IF 6.189. Q1.
• Zamora A, Masana L, Comas-Cufí M, Vila À, Plana N, García-Gil M, Alves-Cabratosa L, Marrugat J, Dégano IR, Ramos R, XULA and ISV-Girona groups.. Familial hypercholesterolemia in a European Mediterranean population-Prevalence and clinical data from 2.5 million primary care patients. J Clin Lipidol 2017; 11: 1013-1022. IF 5.812. D1.
• Sayols-Baixeras S, Subirana I, Fernández-Sanlés A, Sentí M, Lluís-Ganella C, Marrugat J, Elosua R. DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study. Epigenetics 2017; 12(10): 909-916. IF 4.394. Q1.
• Dégano IR, Marrugat J, Grau M, Salvador-González B, Ramos R, Zamora A, Martí R, Elosua R. The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index. Sci Rep 2017; 7: 12370. IF 4.259. Q1.
• Velescu A, Clará A, Martí R, Ramos R, Marcos L, Grau M, Dégano IR, Marrugat J, Elosua R. Abnormally High Ankle-Brachial Index Is Associated with All-cause and Cardiovascular Mortality: The REGICOR Study. Eur J Vasc Endovasc Surg 2017; 54(3): 370-377. IF 4.061. D1.
Ongoing Research Projects
• Epidemiologia de la Hipercolesterolèmia Familiar; predicció de risc, efectivitat i seguretat del tractament hipolipemiant
- Departament de Salut. Generalitat de Catalunya (SLT002/16/00145)
- From 2017 to 2019
- Principal investigator: Marrugat de la Iglesia, Jaume
• Seguiment de la cohort poblacional de l’estudi REGICOR: tendències en la incidència de malaltia cardiovascular, en la prevalença de factors de risc, identificació de nous mecanismes i biomarcadors predictius, i avaluació d’estratègies de prevenció
- Departament de Salut. Generalitat de Catalunya (SLT002/16/00088)
- From 2017 to 2019
- Principal investigator: Elosua Llanos, Roberto
• Role of micro RNAs expressed by human endothelial and vascular smooth muscle cells in myocardial infarction (MIRMID: micro RNAs in Myocardial Infarction Disease)
- Fundación BBVA (PR-16_BIO_CAR_0041)
- From 2016 to 2019
- Principal investigator: Marrugat de la Iglesia, Jaume
• La metilación del ADN y el infarto agudo de miocardio: ¿biomarcador de riesgo y mediador de los efectos de estilos de vida?
- Fondo de Investigación Sanitaria. ISCIII (PI15/00051)
- From 2016 to 2018
- Principal investigator: Elosua Llanos, Roberto
• Papel del microRNA no codificante producido por las células endoteliales y musculares lisas arteriales humanas en el infarto de miocardio
- Fondo de Investigación Sanitaria. ISCIII (PI15/00064)
- From 2016 to 2018
- Principal investigator: Marrugat de la Iglesia, Jaume
• Socioeconomic Status and Cardiovascular Health: Analysis of the Association and of the Mediating Mechanisms
- RECERCAIXA (RE087465)
- From 2015 to 2017
- Principal investigator: Elosua Llanos, Roberto
• Validez y efectividad de un método de auto-cribado del riesgo cardiovascular
- Fondo de Investigación Sanitaria. ISCIII (PI14/00449)
- From 2015 to 2018
- Principal investigator: Grau Magaña, María
• Burden of cardiovascular diseases associated with chronic inflammatory conditions: a population approach
- Fondo de Investigación Sanitaria. ISCIII (CP12/03287)
- From 2013 to 2017
- Principal investigator: Grau Magaña, María
Participation in Research Networks
• Red Cardiovascular
- Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS (RD12/0042/0061)
- Principal investigator: Marrugat de la Iglesia, Jaume
• Red Cardiovascular
- Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS (RD12/0042/0013)
- Principal investigator: Elosua Llanos, Roberto
• CIBER Enfermedades Cardiovasculares
- Fondo de Investigación Sanitaria. ISCIII (CB16/11/00246)
- Principal investigator: Elosua Llanos, Roberto
• CIBER Enfermedades Cardiovasculares
- Fondo de Investigación Sanitaria. ISCIII (CB16/11/00229)
- Principal investigator: Marrugat de la Iglesia, Jaume
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de recerca consolidat REGICOR (REgistre Gironí del Cor) (2017-2019)
- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 222)
- Principal investigator: Marrugat de la Iglesia, Jaume
Theses
• Velescu A. Arteriopatía obliterante de extremidades inferiores en una población Mediterránea: epidemiología y asociación con enfermedad cardiovascular. Autonomous University of Barcelona
- Director: Elosua Llanos, Roberto; Clarà Velasco, Albert; Grande Luis
- Date of defense: 19/05/2017
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(+34) 93 316 04 00
info@imim.es